大戟科植物三叶崖爬藤中的黄酮和二苯乙烯衍生物。

Flavonoid and stilbene derivatives from Macaranga trichocarpa.

机构信息

Chemistry Department, Airlangga University, Jalan Darmawangsa Dalam, Surabaya 60222, Indonesia.

Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

出版信息

Fitoterapia. 2018 Apr;126:74-77. doi: 10.1016/j.fitote.2017.10.001. Epub 2017 Oct 3.

DOI:10.1016/j.fitote.2017.10.001

PMID:28986263

Abstract

A new farnesylated flavonol (4'-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC was 3.5μM.

摘要

从大琴叶榕的叶子中分离得到一个新的法呢基化黄酮醇（4'-O-甲基马卡吉苷）和一个新的香叶基化二苯乙烯（马卡曲醇 H），以及 8 个已知的酚类化合物。这些化合物的结构是根据 NMR 和质谱光谱数据确定的。对分离得到的化合物进行了对 P-388 细胞的细胞毒性测试，结果表明马卡曲醇 G 是最具活性的化合物，IC 为 3.5μM。