一种来自伏生石豆兰（Nervilia fordii (Hance) Schltr.）的乙酰黄酮醇

An acetyl flavonol from Nervilia fordii (Hance) Schltr.

作者信息

Zhou Guang-Xiong, Lu Chuan-Li, Wang Heng-Shan, Yao Xin-Sheng

机构信息

Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research, College of Pharmacy, Jinan University, Guangzhou, China.

出版信息

J Asian Nat Prod Res. 2009 Jun;11(6):498-502. doi: 10.1080/10286020902893074.

DOI:10.1080/10286020902893074

PMID:20183281

Abstract

A new acetyl flavonol, named 3-O-acetyl-7-O-methyl kaemferol (1), together with the five known compounds rhamnocitrin (2), rhamnocitrin-3-O-beta-d-glucoside (3), rhamnocitrin-4'-beta-d-glucoside (4), rhamnazin (5), and p-hydroxyl benzoic acid (6) was isolated from Nervilia fordii (Hance) Schltr. The structures of the compounds were determined by spectroscopic analysis. All the compounds were evaluated against nitric oxide (NO) release, based on the production of NO in mice RAW264.7 stimulated by lipopolysaccharide (LPS). This new compound (1) showed potent inhibitory activity against the production of NO in RAW264.7 stimulated by LPS with the IC50 value of 16.79 microM.

摘要

从香港石豆兰（Nervilia fordii (Hance) Schltr.）中分离出一种新的乙酰黄酮醇，命名为3 - O - 乙酰基 - 7 - O - 甲基山奈酚（1），以及五种已知化合物鼠李柠檬素（2）、鼠李柠檬素 - 3 - O - β - D - 葡萄糖苷（3）、鼠李柠檬素 - 4'- β - D - 葡萄糖苷（4）、鼠李嗪（5）和对羟基苯甲酸（6）。通过光谱分析确定了这些化合物的结构。基于脂多糖（LPS）刺激的小鼠RAW264.7细胞中一氧化氮（NO）的产生，对所有化合物进行了一氧化氮释放评估。这种新化合物（1）对LPS刺激的RAW264.7细胞中NO的产生表现出强大的抑制活性，IC50值为16.79 microM。