神经酸侧链甾体糖苷 I-J：来自.
Nervisides I-J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from .
机构信息
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100803, Vietnam.
Institute of Applied Sciences, Ho Chi Minh City University of Technology (HUTECH), 475 A Dien Bien Phu Street, Ward 25, Binh Thanh District, Ho Chi Minh City 758307, Viet Nam.
出版信息
Molecules. 2019 Jul 17;24(14):2599. doi: 10.3390/molecules24142599.
Two new cycloartane glycosides, nervisides I-J, were isolated from whole plants. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data. These cycloartanes comprised a stereogenic center at C-24, the configuration of which was assigned based on DFT-NMR calculations and the subsequent DP4 probability score. These compounds were tested for cytotoxicity against K562 and MCF-7 tumor cell lines, revealing mild cytotoxic activity.
从全株植物中分离得到两种新的环阿尔廷甾烷糖苷，命名为 nervisides I-J。通过高分辨质谱和一维、二维核磁数据解析， unambiguously 确定了它们的结构。这些环阿尔廷甾烷类化合物在 C-24 位含有一个手性中心，其构型是根据 DFT-NMR 计算和随后的 DP4 概率得分确定的。这些化合物对 K562 和 MCF-7 肿瘤细胞系的细胞毒性进行了测试，显示出温和的细胞毒性活性。
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