来自柔弱叶下珠的一种新型环氧乙烷-呋喃香豆素——德贝拉内酯的抗肝毒性活性。

Antihepatotoxic activity of debelalactone, a new oxirano-furanocoumarin from Phyllanthus debilis.

作者信息

Ahmed Bahar, Khan Shamshir, Verma Amita

机构信息

Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, India.

出版信息

J Asian Nat Prod Res. 2009 Aug;11(8):687-92. doi: 10.1080/10286020802621864.

DOI:10.1080/10286020802621864

PMID:20183308

Abstract

The whole plant of Phyllanthus debilis (Euphorbiacae) afforded a new oxirano-furanocoumarin, characterized as 5-hydroxy-7-methoxy-furanocoumarin-9(14)-cyclohex-12(13)-oxirano-11-one (1), named as debelalactone. Debelalactone exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 59.14%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 61.84%, and alkaline phosphatase (ALP) by 85.93%; while the total protein (TP) levels were increased by 110.35%, when compared with standard drug silymarin that have decreased SGOT by 77.03%, SGPT by 69.67%, ALP by 93.18%, and increased TP levels by 100.48%, respectively, against CCl(4)-induced toxicity in Wistar rats. These biochemical observations were also supplemented by histopathological examinations of the liver sections.

摘要

柔弱叶下珠（大戟科）全草分离得到一种新的环氧乙烷-呋喃香豆素，鉴定为5-羟基-7-甲氧基-呋喃香豆素-9(14)-环己-12(13)-环氧乙烷-11-酮（1），命名为debelalactone。Debelalactone具有显著的抗肝毒性活性，可使血清谷氨酸草酰乙酸转氨酶（SGOT）水平升高降低59.14%，血清谷氨酸丙酮酸转氨酶（SGPT）水平升高降低61.84%，碱性磷酸酶（ALP）水平升高降低85.93%；与标准药物水飞蓟宾相比，总蛋白（TP）水平升高110.35%，水飞蓟宾对Wistar大鼠四氯化碳诱导的毒性作用使SGOT、SGPT、ALP水平分别降低77.03%、69.67%、93.18%，TP水平升高100.48%。这些生化观察结果也得到了肝脏切片组织病理学检查的补充。