一种来自筋骨草的新单萜酸，具有潜在的抗肝毒性活性。
A new monoterpene acid from Marrubium vulgare with potential antihepatotoxic activity.
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India.
出版信息
Nat Prod Res. 2010 Nov;24(18):1671-80. doi: 10.1080/14786410802280976.
The whole plant of Marrubium vulgare L. afforded a new terpenoid, characterised as p-menthane-5,6-dihydroxy-3-carboxylic acid (1), which has been designated as marrubic acid. Its structure has been elucidated on the basis of spectral and chemical analyses. The compound (1) also exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 40.16%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 35.06%, and alkaline phosphatase (ALP) by 30.51%. On the other hand, total protein (TP) levels were increased by 34.07%, as compared to the standard drug silymarin, which decreased SGOT by 53.04%, SGPT by 55.96%, ALP by 35.87% and increased TP levels by 59.59%. These biochemical observations were also supplemented by histopathological examinations of liver sections.
全株筋骨草（Marrubium vulgare L.）得到了一种新的萜类化合物，被鉴定为 p-薄荷烷-5,6-二羟基-3-羧酸（1），其被命名为筋骨草酸。其结构是基于光谱和化学分析确定的。化合物（1）还通过降低血清谷氨酸草酰乙酸转氨酶（SGOT）升高水平的 40.16%、血清谷氨酸丙酮酸转氨酶（SGPT）升高水平的 35.06%和碱性磷酸酶（ALP）升高水平的 30.51%，表现出显著的抗肝毒性活性。另一方面，与标准药物水飞蓟素相比，总蛋白（TP）水平增加了 34.07%，水飞蓟素降低了 SGOT 的 53.04%、SGPT 的 55.96%、ALP 的 35.87%和增加了 TP 水平的 59.59%。这些生化观察结果也得到了肝切片组织病理学检查的补充。
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