Okabe-Kado J, Honma Y, Hayashi M, Hozumi M
Department of Chemotherapy, Saitama Cancer Center Research Institute, Japan.
Anticancer Res. 1991 Jan-Feb;11(1):181-6.
We examined the effects of transforming growth factors beta(TGF-beta) alone and in combination with 1 alpha,25-dihydroxyvitamin D3 (VD3) on human leukemic cell lines (HEL/S, HL-60 and K562). TGF-beta 1 alone at higher concentrations induced monocytic differentiation of HEL/S cells. Combinations of TGF-beta 1 and VD3 synergistically inhibited cell proliferation and induced monocytic differentiation of HEL/S and HL-60 cells. TGF-beta 2 (a subtype of TGF-beta) and erythroid differentiation factor (EDF/Activin A, a member of the TGF-beta gene family) also inhibited growth and induced monocytic differentiation of HL-60 cells in synergy with VD3. Thus combinations of VD3 and TGF-beta (TGF-beta 1, -beta 2, or EDF) acted synergistically in inhibiting cell proliferation and inducing monocytic differentiation of human leukemia cells.
我们研究了转化生长因子β（TGF-β）单独以及与1α,25-二羟基维生素D3（VD3）联合对人白血病细胞系（HEL/S、HL-60和K562）的影响。单独使用较高浓度的TGF-β1可诱导HEL/S细胞向单核细胞分化。TGF-β1与VD3联合可协同抑制HEL/S和HL-60细胞的增殖并诱导其向单核细胞分化。TGF-β2（TGF-β的一种亚型）和红细胞分化因子（EDF/激活素A，TGF-β基因家族的一员）与VD3协同作用时，也可抑制HL-60细胞的生长并诱导其向单核细胞分化。因此，VD3与TGF-β（TGF-β1、-β2或EDF）联合在抑制人白血病细胞增殖和诱导其向单核细胞分化方面具有协同作用。
