Okabe-Kado J, Honma Y, Hozumi M
Department of Chemotherapy, Saitama Cancer Center Research Institute, Japan.
Leuk Res. 1991;15(8):721-6. doi: 10.1016/0145-2126(91)90075-5.
Erythroid differentiation of human leukemic cell lines (HEL, KU812F and K562) was induced by their treatment with transforming growth factor beta (TGF-beta) or erythroid differentiation factor (EDF/Activin A). Their erythroid differentiation was markedly inhibited by vitamin D3, dexamethasone or 12-O-tetradecanoyl-phorbol-13-acetate, which are known to induce monocytic differentiation of leukemic cells. These results suggest that inducers of monocytic differentiation may switch off cellular regulatory mechanisms for induction by TGF-beta and EDF of erythroid differentiation of leukemia cells.
人白血病细胞系（HEL、KU812F和K562）经转化生长因子β（TGF-β）或红细胞分化因子（EDF/激活素A）处理后可诱导其红细胞分化。维生素D3、地塞米松或12-O-十四酰佛波醇-13-乙酸酯可显著抑制它们的红细胞分化，已知这些物质可诱导白血病细胞的单核细胞分化。这些结果表明，单核细胞分化诱导剂可能会关闭由TGF-β和EDF诱导白血病细胞红细胞分化的细胞调节机制。
