核苷5(15)：新型1,2,4-三唑并[3,4-c]-1,2,4-三唑核苷的合成
Nucleosides 5(15): synthesis of novel 1,2,4-triazolo[3,4-c]-1,2,4-triazole nucleosides.
作者信息
Mosselhi M A N, Neidlein R
机构信息
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2009 Nov;28(11):1095-103. doi: 10.1080/15257770903368377.
Ribosylation of 3-methylthio-5-phenyl-1,2,4-triazole (1) with ribose derivative 2 gave the protected 1,2,4-triazole-nucleoside 3, which reacted with hydrazine hydrate to afford the 3-hydrazino-1,2,4-triazole derivative 5. Reaction of 5 with aromatic aldehydes yielded the corresponding hydrazones 6, which cyclized under bromination in acetic acid to give 8. Debenzoylation of 8 afforded novel 1,2,4-triazolo[3,4-c]-1,2,4-triazole nucleosides 9.
3-甲硫基-5-苯基-1,2,4-三唑（1）与核糖衍生物2进行核糖基化反应得到受保护的1,2,4-三唑核苷3，其与水合肼反应生成3-肼基-1,2,4-三唑衍生物5。5与芳香醛反应生成相应的腙6，其在乙酸中溴化作用下环化得到8。8的脱苯甲酰基反应得到新型1,2,4-三唑并[3,4-c]-1,2,4-三唑核苷9。
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