新型含噻唑 - 4 - 甲酰胺和1,2,4 - 三唑 - 3 - 甲酰胺的芹菜核苷的合成与生物学评价
Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide.
作者信息
Kim Myong Jung, Jeong Lak Shin, Kim Joong Hyup, Shin Ji Hye, Chung Soon Yong, Lee Sang Kook, Chun Moon Woo
机构信息
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2004;23(4):715-24. doi: 10.1081/NCN-120037666.
PMID:15200033
Abstract
In view of biological activities of azole nucleosides and apio-dideoxynucleoside, novel apio nucleoside analogues (1 and 2) with thiazole and triazole base moiety were synthesized using 2,3-O-isopropylidene-apio-beta-D-furanose (3), which was prepared from D-mannose.
摘要
鉴于唑类核苷和阿皮二脱氧核苷的生物活性，使用由D - 甘露糖制备的2,3 - O - 异亚丙基 - 阿皮 - β - D - 呋喃糖（3）合成了具有噻唑和三唑碱基部分的新型阿皮核苷类似物（1和2）。
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