N,N'-二苄基-2,4-二氨基嘧啶-2'-脱氧核糖核苷和1-甲基-2'-脱氧假异胞苷的简便合成方法。
A convenient synthesis of N,N'-dibenzyl-2,4-diaminopyrimidine-2'-deoxyribonucleoside and 1-methyl-2'-deoxypseudoisocytidine.
作者信息
Wellington Kevin W, Ooi Hua Chee, Benner Steven A
机构信息
CSIR Biosciences, Pinelands, Modderfontein, South Africa.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2009 Apr;28(4):275-91. doi: 10.1080/15257770902946090.
PMID:20183581
Abstract
The syntheses of N,N'-dibenzyl-2,4-diaminopyrimidine-2'-deoxyribonucleoside and 1-methyl-2'-deoxypseudoisocytidine via Heck coupling are described. A survey of the attempts to use the Heck coupling to synthesize N,N'-dibenzyl-2,4-diaminopyrimidine-2'-deoxyribonucleoside is provided, indicating a remarkable diversity in outcome depending on the specific heterocyclic partner used.
摘要
描述了通过Heck偶联法合成N，N'-二苄基-2,4-二氨基嘧啶-2'-脱氧核糖核苷和1-甲基-2'-脱氧假异胞苷的过程。提供了使用Heck偶联法合成N，N'-二苄基-2,4-二氨基嘧啶-2'-脱氧核糖核苷的尝试综述，表明根据所使用的特定杂环配偶体，结果存在显著差异。
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