具有抗病毒潜力的新核苷类似物的合成热潮不减：向莫里斯·J·罗宾斯致敬。
The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins.
作者信息
De Clercq Erik
机构信息
Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):586-600. doi: 10.1080/15257770903054159.
PMID:20183603
Abstract
The furo[2,3-d]pyrimidin-2(3H)-one is the key structural determinant in the exquisitely potent activity of its derivatives (R = 2-deoxyribosyl; R' = p-pentylphenyl) against VZV (varicella-zoster virus) replication. [structure: see text].
摘要
呋喃并[2,3 - d]嘧啶 - 2(3H)-酮是其衍生物（R = 2 - 脱氧核糖基；R' = 对戊基苯基）对水痘带状疱疹病毒（VZV）复制具有极强活性的关键结构决定因素。[结构：见正文]
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