De Clercq Erik
Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.
Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):586-600. doi: 10.1080/15257770903054159.
The furo[2,3-d]pyrimidin-2(3H)-one is the key structural determinant in the exquisitely potent activity of its derivatives (R = 2-deoxyribosyl; R' = p-pentylphenyl) against VZV (varicella-zoster virus) replication. [structure: see text].
呋喃并[2,3 - d]嘧啶 - 2(3H)-酮是其衍生物(R = 2 - 脱氧核糖基;R' = 对戊基苯基)对水痘带状疱疹病毒(VZV)复制具有极强活性的关键结构决定因素。[结构:见正文]