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1
Inhibition of cytidine deaminase by 2-oxopyrimidine riboside and related compounds.2-氧代嘧啶核糖核苷及相关化合物对胞苷脱氨酶的抑制作用。
Biochem Pharmacol. 1980 Mar 1;29(5):830-2. doi: 10.1016/0006-2952(80)90566-3.
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Rates of spontaneous disintegration of DNA and the rate enhancements produced by DNA glycosylases and deaminases.DNA的自发分解速率以及DNA糖基化酶和脱氨酶所产生的速率增强。
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3
The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse.来自小鼠的同四聚体胞苷脱氨酶的1.48埃分辨率晶体结构。
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Origin of tight binding of a near-perfect transition-state analogue by cytidine deaminase: implications for enzyme catalysis.胞苷脱氨酶对近乎完美的过渡态类似物的紧密结合起源：对酶催化的启示
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Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.泽布勒林增强5-氮杂-2'-脱氧胞苷对L1210白血病的抗肿瘤作用。
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Structure of human cytidine deaminase bound to a potent inhibitor.与一种强效抑制剂结合的人胞苷脱氨酶的结构
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Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.实验证据和结构证据表明，疱疹病毒1型激酶和细胞DNA聚合酶根据糖的构象进行区分。
J Am Chem Soc. 2004 Jan 21;126(2):543-9. doi: 10.1021/ja037929e.
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Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside.
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Is the anomeric effect an important factor in the rate of adenosine deaminase catalyzed hydrolysis of purine nucleosides? A direct comparison of nucleoside analogues constructed on ribose and carbocyclic templates with equivalent heterocyclic bases selected to promote hydration.
Bioorg Med Chem. 2002 Aug;10(8):2723-30. doi: 10.1016/s0968-0896(02)00099-8.
10
Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution.枯草芽孢杆菌四聚体胞苷脱氨酶的晶体结构，分辨率为2.0埃。
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作为脱氨酶底物的腺苷和胞苷的构象锁定碳环核苷的对比行为。

Contrasting behavior of conformationally locked carbocyclic nucleosides of adenosine and cytidine as substrates for deaminases.

作者信息

Marquez Victor E, Schroeder Gottfried K, Ludek Olaf R, Siddiqui Maqbool A, Ezzitouni Abdallah, Wolfenden Richard

机构信息

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):614-32. doi: 10.1080/15257770903091904.

DOI:10.1080/15257770903091904
PMID:20183605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2910114/
Abstract

In addition to the already known differences between adenosine deaminase (ADA) and cytidine deaminase (CDA) in terms of their tertiary structure, the sphere of Zn(+2) coordination, and their reverse stereochemical preference, we present evidence that the enzymes also differ significantly in terms of the North/South conformational preferences for their substrates and the extent to which the lack of the O(4') oxygen affects the kinetics of the enzymatic deamination of carbocyclic substrates. The carbocyclic nucleoside substrates used in this study have either a flexible cyclopentane ring or a rigid bicyclo[3.1.0]hexane scaffold.

摘要

除了已知的腺苷脱氨酶（ADA）和胞苷脱氨酶（CDA）在三级结构、Zn(+2)配位范围以及相反的立体化学偏好方面存在差异外，我们还提供了证据表明，这两种酶在底物的南北构象偏好以及O(4')氧的缺失对碳环底物酶促脱氨动力学的影响程度方面也存在显著差异。本研究中使用的碳环核苷底物具有灵活的环戊烷环或刚性的双环[3.1.0]己烷骨架。