近红外共振金/金硫化物纳米粒子作为光热癌症治疗剂。
Near-infrared-resonant gold/gold sulfide nanoparticles as a photothermal cancer therapeutic agent.
机构信息
Department of Bioengineering, Rice University MS-142, 6100 S. Main St., Houston, TX 77251, USA.
出版信息
Small. 2010 Mar 22;6(6):745-52. doi: 10.1002/smll.200901557.
Abstract
The development and optimization of near-infrared (NIR)-absorbing nanoparticles for use as photothermal cancer therapeutic agents has been ongoing. This work exploits the properties of gold/gold sulfide NIR-absorbing nanoparticles (approximately 35-55 nm) that provide higher absorption (98% absorption and 2% scattering for gold/gold sulfide versus 70% absorption and 30% scattering for gold/silica nanoshells) as well as potentially better tumor penetration. The ability to ablate tumor cells in vitro and efficacy for photothermal cancer therapy is demonstrated, and an in vivo model shows significantly increased long-term, tumor-free survival. Furthermore, enhanced circulation and biodistribution is observed in vivo. This class of NIR-absorbing nanoparticles has the potential to improve upon photothermal tumor ablation for cancer therapy.
摘要
近红外（NIR）吸收纳米粒子作为光热癌症治疗剂的开发和优化一直在进行。这项工作利用了金/金硫化物 NIR 吸收纳米粒子（约 35-55nm）的特性，其提供了更高的吸收率（金/金硫化物的吸收率为 98%，散射率为 2%，而金/二氧化硅纳米壳的吸收率为 70%，散射率为 30%），并且可能具有更好的肿瘤穿透性。体外消融肿瘤细胞的能力以及光热癌症治疗的疗效得到了证明，体内模型显示出明显提高的长期无肿瘤生存率。此外，还观察到体内循环和生物分布的增强。这类 NIR 吸收纳米粒子有可能改善光热肿瘤消融用于癌症治疗。
相似文献
1
Near-infrared-resonant gold/gold sulfide nanoparticles as a photothermal cancer therapeutic agent.
Small. 2010 Mar 22;6(6):745-52. doi: 10.1002/smll.200901557.
2
Gold nanocages as photothermal transducers for cancer treatment.
Small. 2010 Apr 9;6(7):811-7. doi: 10.1002/smll.200902216.
3
Investigation of biodistribution and tissue penetration of PEGylated gold nanostars and their application for photothermal cancer treatment in tumor-bearing mice.
J Mater Chem B. 2020 Jan 7;8(1):65-77. doi: 10.1039/c9tb02194a. Epub 2019 Nov 26.
4
Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer.
Eur J Radiol. 2014 Jan;83(1):117-22. doi: 10.1016/j.ejrad.2013.09.010. Epub 2013 Sep 21.
5
Single Particle and PET-based Platform for Identifying Optimal Plasmonic Nano-Heaters for Photothermal Cancer Therapy.
Sci Rep. 2016 Aug 2;6:30076. doi: 10.1038/srep30076.
6
Infrared-transparent gold nanoparticles converted by tumors to infrared absorbers cure tumors in mice by photothermal therapy.
PLoS One. 2014 Feb 10;9(2):e88414. doi: 10.1371/journal.pone.0088414. eCollection 2014.
7
Tuning photothermal properties of gold nanodendrites for in vivo cancer therapy within a wide near infrared range by simply controlling their degree of branching.
Biomaterials. 2016 Oct;104:138-44. doi: 10.1016/j.biomaterials.2016.06.033. Epub 2016 Jun 24.
8
Plasmonic photothermal therapy (PPTT) using gold nanoparticles.
Lasers Med Sci. 2008 Jul;23(3):217-28. doi: 10.1007/s10103-007-0470-x. Epub 2007 Aug 3.
9
Green synthesis of anisotropic gold nanoparticles for photothermal therapy of cancer.
ACS Appl Mater Interfaces. 2014 Jun 11;6(11):8080-9. doi: 10.1021/am500302t. Epub 2014 May 20.
10
In Vitro and In Vivo Tumor Targeted Photothermal Cancer Therapy Using Functionalized Graphene Nanoparticles.
Biomacromolecules. 2015 Nov 9;16(11):3519-29. doi: 10.1021/acs.biomac.5b00944. Epub 2015 Oct 15.
引用本文的文献
1
Gold Nanoparticles for Photothermal and Photodynamic Therapy.
ACS Omega. 2024 Oct 23;9(44):44846-44859. doi: 10.1021/acsomega.4c08797. eCollection 2024 Nov 5.
2
Green Synthesis of Carbon Nanoparticles (CNPs) from Biomass for Biomedical Applications.
Int J Mol Sci. 2023 Jan 5;24(2):1023. doi: 10.3390/ijms24021023.
3
NIR laser-responsive liquid metal-loaded polymeric hydrogels for controlled release of doxorubicin.
RSC Adv. 2019 Apr 29;9(23):13026-13032. doi: 10.1039/c9ra02286d. eCollection 2019 Apr 25.
4
Devising Hyperthermia Dose of NIR-Irradiated CsWO Nanoparticles for HepG2 Hepatic Cancer Cells.
Nanoscale Res Lett. 2021 Jun 26;16(1):108. doi: 10.1186/s11671-021-03565-4.
5
Engineering of bioactive metal sulfide nanomaterials for cancer therapy.
J Nanobiotechnology. 2021 Mar 31;19(1):93. doi: 10.1186/s12951-021-00839-y.
6
Gold Nanoparticles: A New Golden Era in Oncology?
Pharmaceuticals (Basel). 2020 Aug 12;13(8):192. doi: 10.3390/ph13080192.
7
Fractionated photothermal therapy in a murine tumor model: comparison with single dose.
Int J Nanomedicine. 2019 Jul 18;14:5369-5379. doi: 10.2147/IJN.S205409. eCollection 2019.
8
Probing the surface-localized hyperthermia of gold nanoparticles in a microwave field using polymeric thermometers.
Chem Sci. 2015 Oct 1;6(10):5662-5669. doi: 10.1039/c5sc01535a. Epub 2015 Jul 10.
9
Inorganic nanoparticles in diagnosis and treatment of breast cancer.
J Biol Inorg Chem. 2018 May;23(3):331-345. doi: 10.1007/s00775-018-1542-z. Epub 2018 Feb 16.
10
Self-quenched ferrocenyl diketopyrrolopyrrole organic nanoparticles with amplifying photothermal effect for cancer therapy.
Chem Sci. 2017 Nov 1;8(11):7457-7463. doi: 10.1039/c7sc03351f. Epub 2017 Sep 5.
本文引用的文献
1
Rapid synthesis of small silver nanocubes by mediating polyol reduction with a trace amount of sodium sulfide or sodium hydrosulfide.
Chem Phys Lett. 2006 Dec 11;432(4-6):491-496. doi: 10.1016/j.cplett.2006.10.095.
2
Immunonanoshells for targeted photothermal ablation of tumor cells.
Int J Nanomedicine. 2006;1(2):149-54. doi: 10.2147/nano.2006.1.2.149.
3
Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy.
Nano Lett. 2007 Jul;7(7):1929-34. doi: 10.1021/nl070610y. Epub 2007 Jun 6.
4
Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells.
Nano Lett. 2007 May;7(5):1318-22. doi: 10.1021/nl070345g. Epub 2007 Apr 13.
5
Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods.
Nano Lett. 2007 Apr;7(4):941-5. doi: 10.1021/nl062962v. Epub 2007 Mar 3.
6
Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity.
Small. 2005 Mar;1(3):325-7. doi: 10.1002/smll.200400093.
7
PEG-modified gold nanorods with a stealth character for in vivo applications.
J Control Release. 2006 Sep 12;114(3):343-7. doi: 10.1016/j.jconrel.2006.06.017. Epub 2006 Jun 23.
8
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
Nano Lett. 2006 Apr;6(4):662-8. doi: 10.1021/nl052396o.
9
Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods.
J Am Chem Soc. 2006 Feb 15;128(6):2115-20. doi: 10.1021/ja057254a.
10
Drug delivery to tumours: recent strategies.
J Pharm Pharmacol. 2005 Oct;57(10):1231-42. doi: 10.1211/jpp.57.10.0001.
Zotero 插件