近红外共振金/金硫化物纳米粒子作为光热癌症治疗剂。
Near-infrared-resonant gold/gold sulfide nanoparticles as a photothermal cancer therapeutic agent.
机构信息
Department of Bioengineering, Rice University MS-142, 6100 S. Main St., Houston, TX 77251, USA.
出版信息
Small. 2010 Mar 22;6(6):745-52. doi: 10.1002/smll.200901557.
Abstract
The development and optimization of near-infrared (NIR)-absorbing nanoparticles for use as photothermal cancer therapeutic agents has been ongoing. This work exploits the properties of gold/gold sulfide NIR-absorbing nanoparticles (approximately 35-55 nm) that provide higher absorption (98% absorption and 2% scattering for gold/gold sulfide versus 70% absorption and 30% scattering for gold/silica nanoshells) as well as potentially better tumor penetration. The ability to ablate tumor cells in vitro and efficacy for photothermal cancer therapy is demonstrated, and an in vivo model shows significantly increased long-term, tumor-free survival. Furthermore, enhanced circulation and biodistribution is observed in vivo. This class of NIR-absorbing nanoparticles has the potential to improve upon photothermal tumor ablation for cancer therapy.
摘要
近红外（NIR）吸收纳米粒子作为光热癌症治疗剂的开发和优化一直在进行。这项工作利用了金/金硫化物 NIR 吸收纳米粒子（约 35-55nm）的特性，其提供了更高的吸收率（金/金硫化物的吸收率为 98%，散射率为 2%，而金/二氧化硅纳米壳的吸收率为 70%，散射率为 30%），并且可能具有更好的肿瘤穿透性。体外消融肿瘤细胞的能力以及光热癌症治疗的疗效得到了证明，体内模型显示出明显提高的长期无肿瘤生存率。此外，还观察到体内循环和生物分布的增强。这类 NIR 吸收纳米粒子有可能改善光热肿瘤消融用于癌症治疗。
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