Goldman Noreen, Dowd Jennifer B
Office of Population Research, Princeton University, Princeton, New Jersey 08544, USA.
Biodemography Soc Biol. 2009;55(2):140-58. doi: 10.1080/19485560903382437.
The inclusion of biomarkers in social surveys such as the Panel Study of Income Dynamics (PSID) has the potential to answer many elusive questions in social science and public health, including the much-studied relationship between socioeconomic status and health. This article reviews the potential inclusion of biomarkers of cardiovascular and metabolic risk in the PSID. We first discuss the considerable analytical benefits of adding these biomarkers to the PSID, including the exploration of life course hypotheses and the potential to test causal relationships between the social environment and biological systems. Next, we review evidence on the reliability of self-reports of cardiovascular and metabolic risk factors, concluding that the potential bias from relying on self-reports may be substantial. Based on evidence of biological importance as well as practical considerations of ease of in-home collection, our first tier of recommended biomarkers includes measured height, weight, waist and hip circumference, diastolic and systolic blood pressure, resting heart rate, total and high-density lipoprotein (HDL) cholesterol, glycosylated hemoglobin (HbA1c), C-reactive protein (CRP), and cystatin C. Additional markers of secondary priority are also discussed.
在诸如收入动态面板研究(PSID)等社会调查中纳入生物标志物,有可能回答社会科学和公共卫生领域中许多难以捉摸的问题,包括人们深入研究的社会经济地位与健康之间的关系。本文回顾了在PSID中纳入心血管和代谢风险生物标志物的可能性。我们首先讨论了将这些生物标志物添加到PSID中的诸多分析益处,包括对生命历程假设的探索以及检验社会环境与生物系统之间因果关系的潜力。接下来,我们回顾了关于心血管和代谢风险因素自我报告可靠性的证据,得出结论:依赖自我报告可能存在的偏差可能很大。基于生物学重要性的证据以及家庭采集便利性的实际考虑,我们推荐的一级生物标志物包括测量身高、体重、腰围和臀围、舒张压和收缩压、静息心率、总胆固醇和高密度脂蛋白(HDL)胆固醇、糖化血红蛋白(HbA1c)、C反应蛋白(CRP)和胱抑素C。还讨论了二级优先的其他标志物。