Tepper B J, Friedman M I
Monell Chemical Senses Center, Philadelphia.
Appetite. 1991 Feb;16(1):25-38. doi: 10.1016/0195-6663(91)90108-5.
Two experiments examined the ingestive responses of streptozotocin-diabetic rats fed low-fat or high-fat diets to glucose, fructose, sucrose and maltose solutions in brief (30 min) intake tests. In Experiment 1, one-bottle acceptability tests were used whereas two-bottle preference tests were used in Experiment 2. Three main findings resulted from these studies. Firstly, diabetic rats fed the low-fat diet displayed a reduced acceptance of and preference for all concentrated sugar solutions. Secondly, glucose consumption patterns of diabetic rats fed the low-fat diet were distinctly different from their responses to the other sugars. Thirdly feeding high-fat diets, either high or low in carbohydrate, normalized the responses of diabetic rats to the sugar solutions. The results suggest that feeding high-fat diets to diabetic rats normalizes their responses to sugar solutions because of reductions in hunger and thirst associated with the provision of a utilizable source of calories and an improvement in body fluid balance.
两项实验在短期（30分钟）摄入测试中，研究了喂食低脂或高脂饮食的链脲佐菌素诱导的糖尿病大鼠对葡萄糖、果糖、蔗糖和麦芽糖溶液的摄取反应。在实验1中，采用单瓶接受性测试，而在实验2中采用双瓶偏好性测试。这些研究得出了三个主要发现。首先，喂食低脂饮食的糖尿病大鼠对所有浓缩糖溶液的接受度和偏好降低。其次，喂食低脂饮食的糖尿病大鼠的葡萄糖消耗模式与它们对其他糖类的反应明显不同。第三，喂食高脂饮食，无论碳水化合物含量高或低，都使糖尿病大鼠对糖溶液的反应正常化。结果表明，给糖尿病大鼠喂食高脂饮食可使其对糖溶液的反应正常化，这是因为提供了可利用的卡路里来源后饥饿和口渴感减轻，以及体液平衡得到改善。
