Bellush L L, Rowland N
Physiol Behav. 1985 Sep;35(3):319-27. doi: 10.1016/0031-9384(85)90303-8.
Streptozotocin-diabetic male rats were hyperphagic relative to nondiabetic controls when offered only high carbohydrate (CHO) laboratory chow. Diabetics and controls ate about the same amount of high fat diets made from 67% w/w chow and 33% either coconut oil (saturated) or safflower oil (unsaturated). However, when offered a simultaneous choice of high fat diets and chow, nondiabetics and low dose (35 mg/kg) streptozotocin-diabetics showed a preference for the high fat diet: in contrast the high dose (65 mg/kg) streptozotocin diabetics developed a preference for chow. When pairs of isocaloric synthetic diets were offered, diabetics again preferred low fat/high CHO to high fat/low CHO diets, but the actual intake of fat was not constant across different diet pairs. Nondiabetics also selected away from the high fat diets in these synthetic diet pairs, even when saccharin was added to the high fat diet in an attempt to equate its sweetness with that of the paired low fat-high CHO diet. Plasma ketone levels of diabetics during obligatory high fat diet consumption were negatively correlated with their subsequent preference for the fat diet over simultaneously-offered chow. These data show that strong dietary preferences do not develop for fat in diabetics and suggest that high fat diets do not have net beneficial postingestional effects in these rats.
当仅提供高碳水化合物（CHO）实验室饲料时，链脲佐菌素诱导的糖尿病雄性大鼠相对于非糖尿病对照组食欲亢进。糖尿病大鼠和对照组摄入的由67%（w/w）饲料和33%椰子油（饱和）或红花油（不饱和）制成的高脂肪饮食量大致相同。然而，当同时提供高脂肪饮食和饲料供选择时，非糖尿病大鼠和低剂量（35mg/kg）链脲佐菌素诱导的糖尿病大鼠表现出对高脂肪饮食的偏好：相反，高剂量（65mg/kg）链脲佐菌素诱导的糖尿病大鼠则表现出对饲料的偏好。当提供等热量的合成饮食对时，糖尿病大鼠再次表现出偏好低脂/高CHO饮食而非高脂/低CHO饮食，但不同饮食对之间脂肪的实际摄入量并不恒定。在这些合成饮食对中，非糖尿病大鼠也会避开高脂肪饮食，即使在高脂肪饮食中添加糖精以使其甜度与配对的低脂-高CHO饮食相等时也是如此。糖尿病大鼠在强制食用高脂肪饮食期间的血浆酮水平与其随后对高脂肪饮食相对于同时提供的饲料的偏好呈负相关。这些数据表明，糖尿病大鼠不会对脂肪形成强烈的饮食偏好，并表明高脂肪饮食对这些大鼠没有净有益的餐后效应。
