球孢白僵菌对姜黄素的4'-O-甲基糖基化作用。
4'-O-methylglycosylation of curcumin by Beauveria bassiana.
作者信息
Zeng Jia, Yang Nan, Li Xiu-Min, Shami Paul J, Zhan Jixun
机构信息
Department of Biological and Irrigation Engineering, Utah State University, Logan, UT 84322-4105, USA.
出版信息
Nat Prod Commun. 2010 Jan;5(1):77-80.
The applications of curcumin have been limited by its poor water solubility and low bioavailability. In this study, we successfully synthesized a new curcumin derivative, curcumin-8'-O-4"-O-methyl-beta-D-glucopyranoside, by biotransformation with the fungal strain Beauveria bassiana ATCC 7159. The structure of this new product was determined on the basis of spectroscopic data. This is the first record of a curcumin glycoside that has been synthesized by a fungus.
姜黄素的应用因其水溶性差和生物利用度低而受到限制。在本研究中，我们通过球孢白僵菌ATCC 7159菌株的生物转化成功合成了一种新的姜黄素衍生物，姜黄素-8'-O-4"-O-甲基-β-D-吡喃葡萄糖苷。该新产品的结构基于光谱数据确定。这是首次由真菌合成姜黄素糖苷的记录。
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