球孢白僵菌对1-氨基蒽的微生物代谢
Microbial metabolism of 1-aminoanthracene by Beauveria bassiana.
作者信息
Zhan Jixun, Gunatilaka A A Leslie
机构信息
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706-6800, USA.
出版信息
Bioorg Med Chem. 2008 May 1;16(9):5085-9. doi: 10.1016/j.bmc.2008.03.030. Epub 2008 Mar 14.
The carcinogen and mutagen, 1-aminoanthracene, was efficiently metabolized by the fungal strain Beauveria bassiana ATCC 7159 to yield three new metabolites identified as 1-acetamido-5-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthracene, 1-acetamido-8-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthraquinone, and 1-acetamido-6-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthraquinone, together with 1-acetamidoanthracene and 1-acetamidoanthraquinone. Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation.
致癌物及诱变剂1-氨基蒽被球孢白僵菌ATCC 7159菌株高效代谢，产生了三种新的代谢产物，分别鉴定为1-乙酰氨基-5-[(4'-O-甲基-β-D-吡喃葡萄糖基)氧基]蒽、1-乙酰氨基-8-[(4'-O-甲基-β-D-吡喃葡萄糖基)氧基]蒽醌和1-乙酰氨基-6-[(4'-O-甲基-β-D-吡喃葡萄糖基)氧基]蒽醌，同时还产生了1-乙酰氨基蒽和1-乙酰氨基蒽醌。这些代谢产物的形成表明，球孢白僵菌ATCC 7159中1-氨基蒽的代谢途径涉及乙酰化、氧化、羟基化和O-甲基葡萄糖基化。
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