Monhart Z, Grünfeldová H, Janský P, Zvárová J, Faltus V
Interní oddĕlení Nemocnice Znojmo.
Vnitr Lek. 2010 Jan;56(1):21-9.
The aim of this research was to describe (demographic data and cardiovascular disease risk factors) a non-selected patient population with acute myocardial infarction and to evaluate the applied diagnostic and therapeutic approaches.
Data on 3,184 cases of acute myocardial infarction from non-PCI hospitals in Cáslav, Chrudim, Jindrichův Hradec, Kutná Hora, Písek and Znojmo were entered in a pilot register between 2003 and 2007.
ST elevation myocardial infarctions represented 28.5% of registered cases; primary reperfusion was indicated in 68.3% of these cases. Coronarography was indicated in 43.8% of patients in the non-ST elevation myocardial infarction subgroup. When evaluating pharmacotherapy administered during the first 24 hours following admission, a statistically significant increase in pharmacotherapy administration over the 5 years of register existence was observed (the most apparent for clopidrogel--increase from 24.6% to 63.3%). Analysis of medication recommended for use at discharge also revealed significant increase in administration of the recommended medication over the 5 years in all evaluated drug groups--the most significant, once again, for thienopyridines (increase from 34.9% to 49.6%). In-hospital mortality decreased over the 5 years from 15.2% in 2003 to 8.0% in 2007.
The 5-year evaluation of diagnostic and therapeutic approaches applied in patients with acute myocardial infarction in non-PCI hospitals confirmed improvement in care provided, specifically improved adherence to pharmacotherapy as well as interventional treatment guidelines pertinent to this patient group. Together with increased quality of care, we observed a decline in in-hospital mortality of patients with acute myocardial infarction.
本研究旨在描述(人口统计学数据和心血管疾病危险因素)非选择性急性心肌梗死患者群体,并评估所采用的诊断和治疗方法。
2003年至2007年间,来自恰斯拉夫、赫鲁迪姆、金德里希夫赫拉代茨、库特纳霍拉、皮塞克和兹诺伊莫非PCI医院的3184例急性心肌梗死病例数据被录入一个试验登记册。
ST段抬高型心肌梗死占登记病例的28.5%;其中68.3%的病例需要进行直接再灌注治疗。非ST段抬高型心肌梗死亚组中43.8%的患者需要进行冠状动脉造影。在评估入院后最初24小时内给予的药物治疗时,发现登记册存在的5年期间药物治疗的使用有统计学意义的增加(氯吡格雷最为明显——从24.6%增加到63.3%)。对出院时推荐使用药物的分析还显示,在所有评估药物组中,推荐药物的使用在5年期间也有显著增加——噻吩并吡啶类药物再次最为显著(从34.9%增加到49.6%)。住院死亡率在5年期间从2003年的15.2%降至2007年的8.0%。
对非PCI医院急性心肌梗死患者应用的诊断和治疗方法进行的5年评估证实了所提供护理的改善,特别是对药物治疗以及与该患者群体相关的介入治疗指南的依从性提高。随着护理质量的提高,我们观察到急性心肌梗死患者的住院死亡率有所下降。