Shatalin Iu V, Shmarev A N
Biofizika. 2010 Jan-Feb;55(1):75-82.
The ability of the flavonoid dihydroquercetin to prevent or accelerate the accumulation of reactive oxygen species and the metabolites of oxidative stress, carbonyl compounds has been studied. It has been shown on a model of oxidation of lecithin that dihydroquercetin exhibits a prooxidant effect in the alkaline region of pH, whereas at neutral and acidic pH values dihydroquercetin is an effective antioxidant. In the presence of ferrous iron ions, which catalyze the Fenton's reaction, dihydroquercetin forms a complex with metal that shows the antioxidant activity in the region of high pH values. It has been found that the oxidation of lecithin in the presence of 20-200 microM ferrous iron is inhibited by dihydroquercetin to a concentration of 3.2 mM. At higher concentration of dihydroquercetin in the presence of ferrous iron, the accumulation of malonic dialdehyde occurs, indicating the presence of the prooxidant activity of dihydroquercetin.
已对类黄酮二氢槲皮素预防或加速活性氧和氧化应激代谢产物羰基化合物积累的能力进行了研究。在卵磷脂氧化模型上已表明，二氢槲皮素在pH碱性区域表现出促氧化作用，而在中性和酸性pH值下，二氢槲皮素是一种有效的抗氧化剂。在催化芬顿反应的亚铁离子存在下，二氢槲皮素与金属形成络合物，该络合物在高pH值区域表现出抗氧化活性。已发现，在20 - 200微摩尔亚铁存在下，卵磷脂的氧化被二氢槲皮素抑制至浓度为3.2毫摩尔。在亚铁存在下，当二氢槲皮素浓度较高时，丙二醛会积累，这表明二氢槲皮素存在促氧化活性。
