Picksak Gesine, Luft Carina, Stichtenoth Dirk O
Zentralapotheke, Medizinische Hochschule Hannover, Carl-Neuberg-StraBe 1, 30623 Hannover, German.
Med Monatsschr Pharm. 2010 Feb;33(2):57-8.
Allergic reactions of parenteral vitamin B12 (cobalamin) for therapy of pernicious anaemia are very rare, but repeatedly described in the literature. In case of allergic reactions oral instead of intravenous substitution of vitamin B12 is tolerated. Very high dosages of vitamin B12 (1,000-2,000 microg per day) are necessary due to the underlying vitamin B12 malabsorption.
用于治疗恶性贫血的肠胃外维生素B12（钴胺素）过敏反应非常罕见，但文献中对此有多次描述。出现过敏反应时，口服而非静脉注射维生素B12可被耐受。由于存在潜在的维生素B12吸收不良，需要非常高剂量的维生素B12（每天1000 - 2000微克）。
