• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

暴露于酸性pH值会导致麻疹病毒血凝素发生不可逆的构象变化。

Exposure to acidic pH causes irreversible conformational changes in the measles virus hemagglutinin.

作者信息

Sheshberadaran H

机构信息

Department of Virology, Karolinska Institute, Stockholm, Sweden.

出版信息

Arch Virol. 1991;117(3-4):305-11. doi: 10.1007/BF01310774.

DOI:10.1007/BF01310774
PMID:2018432
Abstract

Temporary exposure to acidic pH caused the hemagglutinin (H) protein of measles virus to lose hemagglutinating activity and undergo antigenic changes. The antigenic changes, detected as alterations in reactivity of several anti-H protein monoclonal antibodies, were characterised by ELISA and radioimmune precipitation assay. The possible biological instances of such conformational changes within the paramyxovirus H protein are discussed.

摘要

短暂暴露于酸性pH值会导致麻疹病毒的血凝素（H）蛋白失去血凝活性并发生抗原变化。通过酶联免疫吸附测定（ELISA）和放射免疫沉淀试验对以几种抗H蛋白单克隆抗体反应性改变所检测到的抗原变化进行了表征。文中讨论了副粘病毒H蛋白内这种构象变化可能的生物学情况。

相似文献

1
Exposure to acidic pH causes irreversible conformational changes in the measles virus hemagglutinin.暴露于酸性pH值会导致麻疹病毒血凝素发生不可逆的构象变化。
Arch Virol. 1991;117(3-4):305-11. doi: 10.1007/BF01310774.
2
Intracellular processing and antigenic maturation of measles virus hemagglutinin protein.
Arch Virol. 1994;136(3-4):239-53. doi: 10.1007/BF01321055.
3
Antigenic determinants of influenza virus hemagglutinin. XI. Conformational changes detected by monoclonal antibodies.流感病毒血凝素的抗原决定簇。XI. 单克隆抗体检测到的构象变化。
Virology. 1985 Aug;145(1):72-83. doi: 10.1016/0042-6822(85)90202-8.
4
Characterization of epitopes on the measles virus hemagglutinin.
Virology. 1986 Jul 15;152(1):58-65. doi: 10.1016/0042-6822(86)90371-5.
5
Localization of monoclonal antibody epitopes and functional domains in the hemagglutinin protein of measles virus.麻疹病毒血凝素蛋白中单克隆抗体表位和功能域的定位
J Virol. 1995 Mar;69(3):1913-6. doi: 10.1128/JVI.69.3.1913-1916.1995.
6
Monoclonal anti-hemagglutinin antibodies detect irreversible antigenic alterations that coincide with the acid activation of influenza virus A/PR/834-mediated hemolysis.单克隆抗血凝素抗体可检测到与甲型流感病毒A/PR/8/34介导的溶血酸性激活同时发生的不可逆抗原改变。
J Virol. 1983 Oct;48(1):239-48. doi: 10.1128/JVI.48.1.239-248.1983.
7
Changes in the antigenicity of the hemagglutinin molecule of H3 influenza virus at acidic pH.H3流感病毒血凝素分子在酸性pH值下的抗原性变化。
Virology. 1983 Apr 30;126(2):587-99. doi: 10.1016/s0042-6822(83)80015-4.
8
Inhibition of measles virus-induced cell-cell fusion with a monoclonal antibody directed against the haemagglutinin.用一种针对血凝素的单克隆抗体抑制麻疹病毒诱导的细胞间融合。
Viral Immunol. 1987 Spring;1(1):25-34. doi: 10.1089/vim.1987.1.25.
9
An analysis of the properties of monoclonal antibodies directed to epitopes on influenza virus hemagglutinin.针对流感病毒血凝素表位的单克隆抗体特性分析。
Arch Virol. 1990;114(1-2):1-26. doi: 10.1007/BF01311008.
10
Monoclonal antibodies against five structural components of measles virus. I. Characterization of antigenic determinants on nine strains of measles virus.抗麻疹病毒五种结构成分的单克隆抗体。I. 九株麻疹病毒抗原决定簇的特性分析
Virology. 1983 Jul 30;128(2):341-53. doi: 10.1016/0042-6822(83)90261-1.

本文引用的文献

1
The uncoating of paramyxoviruses may not require a low pH mediated step.副粘病毒的脱壳可能不需要低pH介导的步骤。
Virology. 1983 Oct 15;130(1):263-8. doi: 10.1016/0042-6822(83)90138-1.
2
Purification, morphology and antigenic characterization of measles virus envelope components.麻疹病毒包膜成分的纯化、形态学及抗原特性
J Gen Virol. 1984 Feb;65 ( Pt 2):355-66. doi: 10.1099/0022-1317-65-2-355.
3
Monoclonal antibodies against five structural components of measles virus. I. Characterization of antigenic determinants on nine strains of measles virus.
抗麻疹病毒五种结构成分的单克隆抗体。I. 九株麻疹病毒抗原决定簇的特性分析
Virology. 1983 Jul 30;128(2):341-53. doi: 10.1016/0042-6822(83)90261-1.
4
Parameters affecting fusion between Sendai virus and liposomes. Role of viral proteins, liposome composition, and pH.影响仙台病毒与脂质体融合的参数。病毒蛋白、脂质体组成和pH值的作用。
Biochemistry. 1986 Dec 16;25(25):8252-60. doi: 10.1021/bi00373a019.
5
Membrane penetration of Sendai virus glycoproteins during the early stages of fusion with liposomes as determined by hydrophobic photoaffinity labeling.通过疏水光亲和标记法测定仙台病毒糖蛋白在与脂质体融合早期阶段的膜穿透情况。
Proc Natl Acad Sci U S A. 1988 Oct;85(20):7433-7. doi: 10.1073/pnas.85.20.7433.
6
Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: specific and transient association with GRP78-BiP in the endoplasmic reticulum and extensive internalization from the cell surface.副黏病毒5型II型糖蛋白血凝素神经氨酸酶的细胞内成熟与转运：在内质网中与葡萄糖调节蛋白78-免疫球蛋白结合蛋白特异性且短暂的结合以及从细胞表面大量内化
J Cell Biol. 1989 Dec;109(6 Pt 2):3273-89. doi: 10.1083/jcb.109.6.3273.
7
Characterization of epitopes on the measles virus hemagglutinin.
Virology. 1986 Jul 15;152(1):58-65. doi: 10.1016/0042-6822(86)90371-5.
8
Identification of measles virus-specific hemolysis-inihibiting antibodies separate from hemagglutination-inhibiting antibodies.鉴定与血凝抑制抗体分离的麻疹病毒特异性溶血抑制抗体。
Infect Immun. 1975 Feb;11(2):231-9. doi: 10.1128/iai.11.2.231-239.1975.