铜催化的官能化芳基硼酸的氯化反应。

Copper-catalyzed chlorination of functionalized arylboronic acids.

机构信息

Discovery Chemistry, Bristol-Myers Squibb Company, PO Box 4000, Princeton New Jersey 08543, USA.

出版信息

Org Lett. 2010 Mar 19;12(6):1192-5. doi: 10.1021/ol9029337.

PMID:20184339

Abstract

A mild, efficient, Cu(I)-catalyzed method for the conversion of arylboronic acids to aryl chlorides is reported. This method is particularly useful for the conversion of electron-deficient arylboronic acids to aryl chlorides, a transformation that is inefficient in the absence of Cu catalysis.

摘要

报道了一种温和、高效的铜（I）催化芳基硼酸转化为芳基氯化物的方法。该方法特别适用于缺电子芳基硼酸转化为芳基氯化物，在没有铜催化的情况下，这种转化效率很低。