Santarsiere Alessandro, Galgano Pierantonio, Funicello Maria, Lupattelli Paolo, Chiummiento Lucia
Department of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo lucano 10, Potenza 85100, Italy.
Department of Chemistry, University "La Sapienza" of Roma, Piazzale A. Moro 5, Roma 00185, Italy.
ACS Omega. 2025 Jun 25;10(26):27856-27860. doi: 10.1021/acsomega.5c00755. eCollection 2025 Jul 8.
A mild, efficient, eco-friendly method for the regioselective halogenation of arylboronic acids in water has been reported. A transition-metal-free -chlorination of arylboronic acids was performed in water, yielding aryl chlorides. -brominated and iodinated compounds were obtained under the same conditions using the corresponding halide salts. This eco-friendly method operates efficiently, even on activated or nonactivated systems, with good yields and selectivity.
已报道了一种温和、高效、环保的在水中对芳基硼酸进行区域选择性卤化的方法。在水中进行了芳基硼酸的无过渡金属氯化反应，生成芳基氯。在相同条件下使用相应的卤化物盐可得到溴化和碘化化合物。这种环保方法即使在活化或未活化的体系中也能高效运行，具有良好的产率和选择性。
