Karlmark B, Obrink K J
Department of Physiology and Medical Biophysics, University of Uppsala, Uppsala, Sweden.
Scand J Gastroenterol. 1967;2(2):124-8. doi: 10.3109/00365526709180057.
Male Heidenhain pouch dogs were used to evaluate the antidiuretic hormone as a physiological inhibitor of gastric acid secretion. The dogs were stimulated to a constant gastric secretion by food and 40-minute ADH infusions of different concentrations took place. The inhibition was expressed as a percentage and plotted against the dose of ADH. The physiological significance of these doses is discussed and evaluated against already published data on normal concentrations. In our experiments we found that 30 muU/kg min markedly influenced the gastric secretion, which means that this inhibition may well occur under physiological conditions.
雄性海登海因袋犬被用于评估抗利尿激素作为胃酸分泌的生理抑制剂。通过喂食使犬产生持续的胃液分泌，并进行不同浓度的抗利尿激素输注，输注时间为40分钟。抑制作用以百分比表示，并针对抗利尿激素的剂量进行绘图。根据已发表的关于正常浓度的数据，对这些剂量的生理意义进行了讨论和评估。在我们的实验中，我们发现30微单位/千克·分钟显著影响胃液分泌，这意味着这种抑制很可能在生理条件下发生。
