Tomik Barbara, Guiloff Roberto J
Department of Neurology, Jagiellonian University, Krakow, Poland.
Amyotroph Lateral Scler. 2010;11(1-2):4-15. doi: 10.3109/17482960802379004.
Dysarthria is a motor disorder of speech characterized by abnormalities of the articulation and intelligibility of speech. Phonation and the rate of facial movements may also be affected. Understanding the nature and course of dysarthria in amyotrophic lateral sclerosis (ALS) is important because loss of communication prevents patients from participating in many activities, may lead to social isolation, and reduces the quality of life. The goal of management of dysarthria in ALS patients is to optimize communication effectiveness for as long as possible. The information about dysarthria in ALS is dispersed in physiological, pathological, speech therapy, otorhinolaringological and neurological publications. This review summarizes the current state of knowledge on the clinical features, differential diagnosis, pathophysiology, investigations and management of dysarthria in ALS patients. There is a need to compare the different methods used to assess dysarthria and for controlled clinical trials to assess therapeutic strategies.
构音障碍是一种言语运动障碍，其特征为言语清晰度和可懂度异常。发声和面部运动速度也可能受到影响。了解肌萎缩侧索硬化症（ALS）中构音障碍的性质和病程很重要，因为沟通障碍会使患者无法参与许多活动，可能导致社交孤立，并降低生活质量。ALS患者构音障碍管理的目标是尽可能长时间地优化沟通效果。关于ALS中构音障碍的信息分散在生理学、病理学、言语治疗、耳鼻喉科和神经学出版物中。本综述总结了目前关于ALS患者构音障碍的临床特征、鉴别诊断、病理生理学、检查和管理的知识状态。有必要比较用于评估构音障碍的不同方法，并进行对照临床试验以评估治疗策略。
