Sino-German Laboratory for Molecular Medicine, Hypertension Division, Cardiovascular Institute and FuWai Hospital, Chinese Academy of Medical Sciences, Beijing, PR China.
Clin Chem Lab Med. 2010 Apr;48(4):551-4. doi: 10.1515/CCLM.2010.101.
C-reactive protein (CRP) has been shown to contribute to the risk of cardiovascular disease. Several single nucleotide polymorphisms (SNPs) at the CRP locus have been found to be associated with CRP concentrations. We hypothesized that genetic variants associated with high CRP may confer a greater risk of stroke and recurrence. The hypothesis was tested in a case-control study and during follow-up of the case population.
Two genetic variants associated with serum CRP in the CRP gene were genotyped in a Chinese case-control study comprised of 1572 stroke patients and 1485 controls. The case population was followed for a median of 4.5 years (range, 0.1-6.0 years).
During a median 4.5-year follow-up for 1526 stroke patients, 299 recurrent strokes were identified. No association was found between the SNPs or haplotypes of the CRP gene and stroke and its recurrence.
Although these variants and corresponding haplotypes in the CRP gene are associated with serum CRP concentrations, our study does not support that variants and corresponding haplotypes studied here have a major influence on risk of stroke and stroke recurrence. Therefore, we speculate that CRP is not a causal factor for stroke.
C-反应蛋白（CRP）已被证明与心血管疾病的风险有关。在 CRP 基因座上已经发现了几个与 CRP 浓度相关的单核苷酸多态性（SNP）。我们假设与 CRP 升高相关的遗传变异可能会增加中风和复发的风险。该假设在病例对照研究中和对病例人群的随访中进行了检验。
在一项由 1572 例中风患者和 1485 例对照组成的中国病例对照研究中，对 CRP 基因中与血清 CRP 相关的两个遗传变异进行了基因分型。对病例人群进行了中位数为 4.5 年（范围为 0.1-6.0 年）的随访。
在对 1526 例中风患者进行中位数为 4.5 年的随访中，发现 299 例中风复发。CRP 基因的 SNP 或单体型与中风及其复发之间没有关联。
尽管 CRP 基因中的这些变体及其相应的单体型与血清 CRP 浓度相关，但我们的研究并不支持这里研究的变体和相应单体型对中风和中风复发风险有重大影响。因此，我们推测 CRP 不是中风的因果因素。
