Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Neurol Neurochir Pol. 2014 Jan-Feb;48(1):30-4. doi: 10.1016/j.pjnns.2013.12.001. Epub 2014 Jan 23.
Some of the risk factors of ischaemic stroke influence the development of atherosclerosis, which is a significant cause of vascular incidents. An inflammatory component plays a role in pathogenesis of both atherosclerosis and atrial fibrillation, the most important risk factor of embolic strokes. C-reactive protein (CRP) concentration in blood reflects the inflammatory process. Concentration of this protein depends on the CRP gene polymorphism. The aim of the study was to assess the relationship between selected risk factors of stroke and variant of -717A>G (rs2794521) CRP gene polymorphism in population of West Pomerania Province of Poland.
There were 125 consecutive patients with ischaemic stroke analysed, who met the inclusion and exclusion criteria. In all patients, -717A>G CRP gene polymorphism was genotyped and analysed in relation to selected stroke risk factors.
Prevalence of type 2 diabetes was lower in patients with AA genotype of -717A>G CRP gene polymorphism than in patients with other alleles (p=0.017). Subjects with GG genotype had significantly higher concentration of CRP comparing to AG genotype (p=0.023). No correlation was found between -717A>G CRP gene polymorphism and the lipid profile and other selected risk factors of stroke.
In patients with ischaemic stroke in West Pomerania Province, the GG genotype of -717A>G CRP gene polymorphism is associated with significantly higher CRP concentration in relation to AG genotype. Patients with AA genotype may be characterised by lower prevalence of type 2 diabetes.
一些缺血性脑卒中的风险因素会影响动脉粥样硬化的发展，而动脉粥样硬化是血管事件的重要原因。炎症成分在动脉粥样硬化和心房颤动的发病机制中都发挥了作用，心房颤动是栓塞性脑卒中最重要的危险因素。血液中的 C 反应蛋白（CRP）浓度反映了炎症过程。这种蛋白质的浓度取决于 CRP 基因多态性。本研究的目的是评估波兰西波美拉尼亚省人群中风的某些危险因素与 CRP 基因-717A>G（rs2794521）多态性的关系。
对符合纳入和排除标准的 125 例连续缺血性脑卒中患者进行分析。对所有患者进行 CRP 基因-717A>G 多态性的基因分型，并分析其与选定的中风危险因素的关系。
与其他等位基因相比，-717A>G CRP 基因多态性 AA 基因型患者的 2 型糖尿病患病率较低（p=0.017）。GG 基因型患者的 CRP 浓度明显高于 AG 基因型（p=0.023）。-717A>G CRP 基因多态性与血脂谱和其他选定的中风危险因素之间无相关性。
在西波美拉尼亚省缺血性脑卒中患者中，-717A>G CRP 基因多态性 GG 基因型与 AG 基因型相比，CRP 浓度显著升高。AA 基因型患者可能具有较低的 2 型糖尿病患病率。
