Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Clin Endocrinol (Oxf). 2010 Sep;73(3):330-8. doi: 10.1111/j.1365-2265.2010.03798.x. Epub 2010 Feb 23.
To examine the association of serum vitamin D level with metabolic syndrome (MetS) and hypertension (HTN) in middle-aged Korean subjects.
We conducted a population-based, cross-sectional survey of 1330 participants aged over 40 years (median age 65.8 years) in Chungju, Korea, in 2007. The 324 subjects, who were normotensive in 2003 and who attended a follow-up visit 4 years later, were included in an analysis of the association of serum vitamin D level with the risk of HTN.
Serum 25-hydroxy-vitamin D [25(OH)D] and PTH were measured in a central laboratory, using chemiluminescence assays.
The overall prevalence of the MetS in participants of this study was 45.3%. After adjusting for various covariates, subjects in the highest quintile group (61.4-116.8 nmol/l) compared with the lowest quintile group (10.0-29.7 nmol/l) of 25(OH)D had an odds ratio (OR) for having MetS of 0.35 (95% confidence intervals, CI, 0.22-0.56; P for trend <0.001). The median level of 25(OH)D was 46.8 nmol/l among 324 subjects who were normotensive in 2003. After multiple adjustment, the OR was substantially higher for new HTN (OR 2.74; 95% CI 1.40-5.34) in subjects with serum 25(OH)D levels below the median value compared with those above median. The inverse associations of vitamin D and MetS/HTN were unchanged after adjustment for PTH and serum calcium levels. There was no association between PTH and MetS.
We found a strong inverse association of 25(OH)D levels with MetS and HTN in this middle-aged Korean population. Having vitamin D deficiency was associated with an increased risk of having MetS and HTN in this demographic group.
探讨血清维生素 D 水平与代谢综合征（MetS）和高血压（HTN）在中年韩国人群中的关系。
我们对韩国忠州 2007 年的 1330 名年龄在 40 岁以上的人群（中位年龄 65.8 岁）进行了一项基于人群的横断面调查。2003 年血压正常且 4 年后参加随访的 324 名受试者被纳入血清维生素 D 水平与 HTN 风险关联的分析。
使用化学发光法在中央实验室测量血清 25-羟维生素 D [25(OH)D] 和甲状旁腺激素。
该研究参与者的 MetS 总体患病率为 45.3%。在调整了各种混杂因素后，与 25(OH)D 最低五分位数组（10.0-29.7 nmol/L）相比，25(OH)D 最高五分位数组（61.4-116.8 nmol/L）的受试者患 MetS 的比值比（OR）为 0.35（95%置信区间，CI，0.22-0.56；P 趋势<0.001）。2003 年血压正常的 324 名受试者的 25(OH)D 中位数为 46.8 nmol/L。经多次调整后，与血清 25(OH)D 水平低于中位数的受试者相比，血清 25(OH)D 水平低于中位数的新 HTN（OR 2.74；95%CI，1.40-5.34）的 OR 显著更高。调整甲状旁腺激素和血清钙水平后，维生素 D 与 MetS/HTN 的负相关关系不变。甲状旁腺激素与 MetS 之间无关联。
我们发现，在这个中年韩国人群中，25(OH)D 水平与 MetS 和 HTN 呈强负相关。在这个人群中，维生素 D 缺乏与 MetS 和 HTN 的风险增加有关。
