Internal Medicine, Wayne State University, Detroit, MI 48201, USA.
Clin Transplant. 2010 Sep-Oct;24(5):E153-7. doi: 10.1111/j.1399-0012.2010.01209.x.
Among Americans, the risk for kidney disease is higher in individuals of African descent (AA) when compared with Caucasians. We considered whether there are similar racial differences in kidney function soon after donor nephrectomy. Of the 31,928 live kidney donors that donated between the years 2000 and 2005, 16,996 (53%) had post-donation serum creatinine recorded at a mean follow-up of 156 d (range 1-1410 d). A total of 14,525 (85%) were Caucasians and 2471 (15%) were AA. When compared with Caucasians, AA donors were more likely to be younger, heavier, and male, had a higher baseline serum creatinine and a shorter duration of follow-up. After accounting for these differences, the serum creatinine after donation and fractional rise in serum creatinine after donation were similar between the two groups (AA vs. Caucasian donors, 1.3 ± 0.3 vs. 1.2 ± 0.3 mg/dL; 53% vs. 45%) and the post-donation estimated glomerular filtration rate was also similar (57.2 ± 0.6 vs. 56.0 ± 0.2 mL/min per 1.73 m(2)). We observed no major clinical difference in glomerular filtration rate and ability to compensate for loss of renal mass soon after live kidney donation between Caucasian and AA donors.
在美国，与白种人相比，非洲裔美国人（AA）患肾脏疾病的风险更高。我们考虑了在活体肾捐献后，肾功能是否存在类似的种族差异。在 2000 年至 2005 年间进行活体肾捐献的 31928 名供者中，有 16996 名（53%）在平均随访 156 天（范围 1-1410 天）时记录了术后血清肌酐。共有 14525 名（85%）为白种人，2471 名（15%）为 AA。与白种人相比，AA 供者更年轻、更重、更男性化，基线血清肌酐更高，随访时间更短。在考虑到这些差异后，两组供者的术后血清肌酐和术后血清肌酐升高的分数相似（AA 与白种人供者，1.3 ± 0.3 与 1.2 ± 0.3mg/dL；53%与 45%），术后估计肾小球滤过率也相似（57.2 ± 0.6 与 56.0 ± 0.2mL/min/1.73m2）。我们观察到，在活体肾捐献后不久，白种人和 AA 供者的肾小球滤过率和对肾单位丢失的代偿能力没有明显的临床差异。
