Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin, Madison, WI, USA.
Neural Dev. 2010 Feb 25;5:6. doi: 10.1186/1749-8104-5-6.
All-trans retinoic acid (atRA) is required for nervous system development, including the developing hindbrain region. Neuron navigator 2 (Nav2) was first identified as an atRA-responsive gene in human neuroblastoma cells (retinoic acid-induced in neuroblastoma 1, Rainb1), and is required for atRA-mediated neurite outgrowth. In this paper, we explore the importance of Nav2 in nervous system development and function in vivo.
Nav2 hypomorphic homozygous mutants show decreased survival starting at birth. Nav2 mutant embryos show an overall reduction in nerve fiber density, as well as specific defects in cranial nerves IX (glossopharyngeal) and X (vagus). Nav2 hypomorphic mutant adult mice also display a blunted baroreceptor response compared to wild-type controls.
Nav2 functions in mammalian nervous system development, and is required for normal cranial nerve development and blood pressure regulation in the adult.
全反式视黄酸（atRA）是神经系统发育所必需的，包括发育中的后脑区域。神经元导航器 2（Nav2）最初在人神经母细胞瘤细胞（视黄酸诱导的神经母细胞瘤 1，Rainb1）中被鉴定为 atRA 反应性基因，是 atRA 介导的神经突生长所必需的。在本文中，我们探讨了 Nav2 在体内神经系统发育和功能中的重要性。
Nav2 功能缺失性纯合子突变体从出生开始就表现出存活率下降。Nav2 突变体胚胎的神经纤维密度总体减少，颅神经 IX（舌咽）和 X（迷走）也存在特定缺陷。Nav2 功能缺失性突变体成年小鼠的压力感受器反应也比野生型对照迟钝。
Nav2 在哺乳动物神经系统发育中起作用，是正常颅神经发育和成年血压调节所必需的。
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