Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China. [corrected]
Clin Chim Acta. 2010 May 2;411(9-10):771-5. doi: 10.1016/j.cca.2010.02.064. Epub 2010 Feb 23.
Adiponectin and leptin, as the main circulating peptides secreted by adipose tissue, are potential contributors to bone metabolism. However, their association with bone mineral density (BMD) is unknown. We investigated whether these serum adipocytokines concentrations are associated with BMD and bone turnover markers.
Serum adiponectin, leptin concentrations, bone turnover biochemical markers, and BMD were determined in 265 premenopausal and 336 postmenopausal Chinese women.
In postmenopausal Chinese women, the multiple linear stepwise regression analysis showed that year since menopause, lean mass, estradiol, and adiponectin, but not fat mass, leptin, were independent predictors of BMD in postmenopausal Chinese women. However, in premenopausal Chinese women, adiponectin was not the predictor of BMD. The significant positive correlations between adiponectin and bone-specific alkaline phosphatase (BAP), bone cross-linked N-telopeptides of type I collagen (NTX) were found only in postmenopausal women. Serum BAP, and NTX, but not adiponectin, decreased in response to alendronate therapy.
Adiponectin was an independent predictor of BMD, and positively correlated with bone turnover biochemical markers in postmenopausal Chinese women, but not premenopausal women. It suggested that adiponectin may exert a negative effect on bone mass by promoting excessive bone resorption associated with bone loss. However, these effects may be mediated by menopausal status.
脂联素和瘦素作为脂肪组织主要分泌的循环肽，可能是骨代谢的潜在贡献者。然而，它们与骨密度（BMD）的关系尚不清楚。我们研究了这些血清脂肪细胞因子浓度是否与 BMD 和骨转换标志物相关。
测定了 265 名绝经前和 336 名绝经后中国妇女的血清脂联素、瘦素浓度、骨转换生化标志物和 BMD。
在绝经后中国妇女中，多元线性逐步回归分析显示，绝经年限、瘦体重、雌二醇和脂联素，但不是脂肪量、瘦素，是绝经后中国妇女 BMD 的独立预测因子。然而，在绝经前中国妇女中，脂联素不是 BMD 的预测因子。仅在绝经后妇女中发现脂联素与骨特异性碱性磷酸酶（BAP）和 I 型胶原交联 N 末端肽（NTX）之间存在显著正相关。血清 BAP 和 NTX，但不是脂联素，在阿伦膦酸钠治疗后下降。
脂联素是 BMD 的独立预测因子，与绝经后中国妇女的骨转换生化标志物呈正相关，但与绝经前妇女无关。这表明脂联素可能通过促进与骨丢失相关的过度骨吸收对骨量产生负面影响。然而，这些影响可能是由绝经状态介导的。
