Institute of Endocrinology and Metabolism, The Second Xiangya Hospital of Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China.
J Endocrinol Invest. 2010 Nov;33(10):707-11. doi: 10.1007/BF03346674. Epub 2010 Mar 5.
Adiponectin, apelin, leptin, resistin, and visfatin, as the main circulating peptides secreted by adipose tissue, are potential contributors to bone metabolism. However, their association with bone mineral density (BMD) is unclear.
The present study investigated whether these serum adipocytokines levels are associated with BMD and bone turnover markers.
Serum adiponectin, apelin, leptin, resistin, visfatin levels, bone turnover biochemical markers, and BMD were determined in 336 post-menopausal Chinese women (41-81 yr old).
Adiponectin was negatively correlated with fat mass, while leptin had a positive correlation. In the multiple linear stepwise regression analysis, years since menopause, lean mass, estradiol, and adiponectin, but not fat mass, apelin, leptin, resistin, and visfatin, were independent predictors of BMD. The significant positive correlations between adiponectin and bone-specific alkaline phosphatase, bone crosslinked N-telopeptides of type I collagen were found.
Adiponectin was an independent predictor of BMD in post-menopausal Chinese women, and positively correlated with bone turnover biochemical markers. It suggested that adiponectin may exert a negative effect on bone mass by promoting excessive bone resorption associated with bone loss in post-menopausal women.
脂联素、apelin、瘦素、抵抗素和内脂素作为脂肪组织分泌的主要循环肽，可能是骨代谢的潜在贡献者。然而，它们与骨密度（BMD）的关系尚不清楚。
本研究旨在探讨这些血清脂肪细胞因子水平是否与 BMD 和骨转换标志物相关。
测定 336 名绝经后中国女性（41-81 岁）的血清脂联素、apelin、瘦素、抵抗素、内脂素水平、骨转换生化标志物和 BMD。
脂联素与脂肪量呈负相关，而瘦素呈正相关。多元线性逐步回归分析显示，绝经年限、瘦体重、雌二醇和脂联素，而不是脂肪量、apelin、瘦素、抵抗素和内脂素，是 BMD 的独立预测因子。脂联素与骨特异性碱性磷酸酶、I 型胶原交联 N-末端肽呈显著正相关。
脂联素是绝经后中国女性 BMD 的独立预测因子，与骨转换生化标志物呈正相关。这表明脂联素可能通过促进与绝经后妇女骨丢失相关的过度骨吸收对骨量产生负面影响。
