Dip. Scienze Ginecologiche, Ostetriche e Pediatriche, U.O. Genetica Medica, Pol. S.Orsola-Malpighi, Università di Bologna, Italy.
Mol Cell Endocrinol. 2010 May 28;321(1):67-76. doi: 10.1016/j.mce.2010.02.022. Epub 2010 Feb 23.
Thyroid oncocytic neoplasms are tumors composed of cells characterized by an aberrant increase of mitochondrial mass. They represent a subset of thyroid tumors whose classification and clinical features has been a matter of controversy for clinicians and pathologists alike. The prevalence of oncocytic tumors in the thyroid gland, the relevance of the issues debated, and the obvious cellular derangement of oncocytic cells, namely a complete deregulation of the mitochondrial mass and metabolism, have spurred many investigators to study the molecular mechanism underlying the genesis of this peculiar cancer phenotype. Their findings, which are unraveling the tumor pathobiology, are the subject of the present review.
甲状腺嗜酸细胞瘤是由细胞组成的肿瘤，这些细胞的特征是线粒体质量异常增加。它们是甲状腺肿瘤的一个亚群，其分类和临床特征一直是临床医生和病理学家争论的焦点。甲状腺嗜酸细胞瘤的患病率、争议问题的相关性，以及嗜酸细胞明显的细胞紊乱，即线粒体质量和代谢的完全失调，促使许多研究人员研究这种特殊的癌症表型发生的分子机制。他们的研究结果揭示了肿瘤的病理生物学，是本文综述的主题。
