Dipartimento di Ingegneria Civile and Lagrange Laboratory, Università di Roma Tor Vergata, via del Politecnico 1, 00133 Roma, Italy.
J Biomech. 2010 May 28;43(8):1580-9. doi: 10.1016/j.jbiomech.2010.01.033. Epub 2010 Feb 24.
In this paper, starting from a consistent mathematical model, a novel computational approach is proposed for assessing some biomechanical effects on drug release from coronary drug-eluting stents (DESs), related to tissue properties, local hemodynamics and stent design. A multiscale and multidomain advection-diffusion model is formulated for describing drug dynamics in the polymeric substrate covering the stent, into the arterial wall, and in the vessel lumen. The model accounts for tissue microstructure (anisotropic drug diffusion, porosity, drug retention induced by resident proteins), macrostructure (plaque between stent and tissue), and local hemodynamics. In the case of hydrophobic taxus-based compounds, several numerical analyses have been carried out on simplified geometries by using finite element simulations, performing significant comparisons with other recent studies and highlighting general conclusions for assessing effectiveness of some modelling features as well as useful hints for optimizing drug delivery design and technology.
本文从一个一致的数学模型出发，提出了一种新的计算方法，用于评估与组织特性、局部血液动力学和支架设计相关的冠状动脉药物洗脱支架（DES）中药物释放的一些生物力学效应。建立了一个多尺度和多领域的对流-扩散模型，用于描述覆盖支架的聚合物基质、动脉壁和血管腔中的药物动力学。该模型考虑了组织微观结构（各向异性药物扩散、孔隙率、驻留蛋白引起的药物保留）、宏观结构（支架与组织之间的斑块）和局部血液动力学。在疏水性紫杉烷类化合物的情况下，通过有限元模拟对简化几何形状进行了多次数值分析，并与其他最近的研究进行了重要比较，得出了评估某些建模特征有效性的一般结论以及优化药物输送设计和技术的有用提示。
