Migliavacca F, Gervaso F, Prosi M, Zunino P, Minisini S, Formaggia L, Dubini G
Laboratory of Biological Structure Mechanics, Department of Structural Engineering, Politecnico di Milano, Milan, Italy.
Comput Methods Biomech Biomed Engin. 2007 Feb;10(1):63-73. doi: 10.1080/10255840601071087.
The present study illustrates a possible methodology to investigate drug elution from an expanded coronary stent. Models based on finite element method have been built including the presence of the atherosclerotic plaque, the artery and the coronary stent. These models take into account the mechanical effects of the stent expansion as well as the effect of drug transport from the expanded stent into the arterial wall. Results allow to quantify the stress field in the vascular wall, the tissue prolapse within the stent struts, as well as the drug concentration at any location and time inside the arterial wall, together with several related quantities as the drug dose and the drug residence times.
本研究阐述了一种用于研究药物从扩张型冠状动脉支架洗脱的可能方法。基于有限元方法建立了包含动脉粥样硬化斑块、动脉和冠状动脉支架的模型。这些模型考虑了支架扩张的力学效应以及药物从扩张后的支架向动脉壁转运的效应。研究结果能够量化血管壁中的应力场、支架支柱内的组织脱垂情况，以及动脉壁内任意位置和时间的药物浓度，同时还能得出诸如药物剂量和药物驻留时间等几个相关量。
