相互依存的生物系统，多功能分子：组织因子途径抑制剂在抗凝之外的作用不断演变。
Interdependent biological systems, multi-functional molecules: the evolving role of tissue factor pathway inhibitor beyond anti-coagulation.
机构信息
Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
出版信息
Thromb Res. 2010 Apr;125 Suppl 1(Suppl 1):S57-9. doi: 10.1016/j.thromres.2010.01.039. Epub 2010 Feb 24.
Abstract
Coagulation, innate immunity, angiogenesis, and lipid metabolism represent fundamental and interdependent biological systems. While tissue factor pathway inhibitor (TFPI) is the major physiological inhibitor of TF, its unique structure and endothelial expression allow multi-modal interactions with constituent molecules in each of these systems. We review emerging data describing roles for TFPI beyond simply opposing the action of TF, particularly with regard to the highly basic c-terminus of TFPI, and highlight potentially exciting new areas for future research.
摘要
凝血、先天免疫、血管生成和脂质代谢是基本且相互依存的生物学系统。组织因子途径抑制剂（TFPI）是 TF 的主要生理性抑制剂，但因其独特的结构和内皮细胞表达模式，使其能够与上述每个系统中的组成分子发生多种相互作用。我们综述了描述 TFPI 作用的新数据，这些作用不仅限于拮抗 TF 的作用，尤其是 TFPI 的高度碱性 C 末端，并且强调了未来研究的潜在令人兴奋的新领域。
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