长链（E）-3-烯-2-酮的抗菌活性。
Antimicrobial activity of long-chain (E)-3-alken-2-ones.
机构信息
Department of Chemistry, Humboldt State University, Arcata, CA 95521, USA.
出版信息
Bioorg Med Chem Lett. 2010 Mar 15;20(6):1819-20. doi: 10.1016/j.bmcl.2010.02.016. Epub 2010 Feb 8.
(E)-3-tridecen-2-one, a compound identified from the interdigital glands of black-tailed deer (Odocoileus hemionus columbianus), has been shown to inhibit the growth of bacteria and fungi. Homologues of (E)-3-tridecen-2-one were prepared and screened for antimicrobial activity. For the fungus, Trichophyton mentagrophytes, the minimum inhibitory concentration (MIC) of (E)-3-Tetradecen-2-one was 12.5 microg/mL, and for the bacteria, Propionibacterium acnes, the MIC of (E)-3-heptadecen-2-one was 3.13 microg/mL.
(E)-3-十三碳烯-2-酮，一种从黑尾鹿（Odocoileus hemionus columbianus）的趾间腺中鉴定出的化合物，已被证明能抑制细菌和真菌的生长。（E）-3-十三碳烯-2-酮的同源物被制备并筛选其抗菌活性。对于真菌，须癣毛癣菌，（E）-3-十四碳烯-2-酮的最小抑菌浓度（MIC）为 12.5 微克/毫升，对于细菌，痤疮丙酸杆菌，（E）-3-十七碳烯-2-酮的 MIC 为 3.13 微克/毫升。
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