Wilson T, Christie D L
Dept. of Cellular and Molecular Biology, University of Auckland, New Zealand.
Biochem Biophys Res Commun. 1991 Apr 15;176(1):447-52. doi: 10.1016/0006-291x(91)90944-3.
Gravidin, a phospholipase inhibitor characterised previously from amniotic fluid, was partially sequenced at the N-terminal and found to be identical to secretory component of human IgA. Inhibition of antiphospholipase activity was observed after incubation of gravidin with monoclonal antibody to human secretory component. Secretory component isolated from human saliva and breast milk was found to inhibit arachidonic acid release from human lymphocytes. It was concluded that gravidin is secretory component of IgA.
妊娠素是一种先前从羊水鉴定出的磷脂酶抑制剂，对其N端进行了部分测序，发现它与人IgA的分泌成分相同。将妊娠素与抗人分泌成分单克隆抗体一起孵育后，观察到抗磷脂酶活性受到抑制。从人唾液和母乳中分离出的分泌成分被发现可抑制人淋巴细胞中花生四烯酸的释放。得出的结论是，妊娠素是IgA的分泌成分。
