Wilson T, Liggins G C, Joe L
Postgraduate School of Obstetrics and Gynaecology, University of Auckland, National Women's Hospital, New Zealand.
Am J Obstet Gynecol. 1989 Mar;160(3):602-6. doi: 10.1016/s0002-9378(89)80038-9.
Gravidin, a protein that inhibits release of arachidonic acid from human decidual cells, was purified from amniotic fluid. The protein has a molecular weight of 58 to 60 kilodaltons, an isoelectric point of 8.4, and physical characteristics that are indistinguishable from those of inhibitor II previously described. Activity was determined in a dispersed decidual cell system that released arachidonic acid in response to either histamine or calcium ionophore and in a cell-free assay of phospholipase A2. Protein purified from incubates of chorion obtained after the onset of labor was significantly less active than that from chorion obtained before the onset of labor.
孕体素是一种能抑制花生四烯酸从人蜕膜细胞中释放的蛋白质，它是从羊水 中提纯出来的。该蛋白质分子量为58至60千道尔顿，等电点为8.4，其物理特性与先前描述的抑制剂II无法区分。活性是在一个分散的蜕膜细胞系统中测定的，该系统会因组胺或钙离子载体而释放花生四烯酸，同时也在磷脂酶A2的无细胞检测中进行测定。从分娩开始后获得的绒毛膜培养物中纯化出的蛋白质，其活性明显低于分娩开始前获得的绒毛膜中的蛋白质。
