镰状细胞病患者血浆不对称二甲基精氨酸浓度与溶血性表型相关。
Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype.
机构信息
Immunology Laboratory Department, Red Cross Blood Bank Foundation Curaçao, Curaçao, Netherlands Antilles.
出版信息
Blood Cells Mol Dis. 2010 Apr 15;44(4):229-32. doi: 10.1016/j.bcmd.2010.02.005. Epub 2010 Feb 24.
Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbSbeta(0)-thalassemia and 24 HbSC/HbSbeta(+)-thalassemia patients. As expected ADMA levels were higher in HbSS/HbSbeta(0)-thalassemia patients with PHT (p=0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p=0.012), cholelithiasis (p=0.008) and priapism (p=0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD.
不对称二甲基精氨酸（ADMA）与镰状细胞病（SCD）中的肺动脉高压（PHT）有关。我们研究了 ADMA 与其他 SCD 相关并发症的关系。在 52 名 HbSS/HbSβ(0)-地中海贫血和 24 名 HbSC/HbSβ(+)-地中海贫血患者中测定了血浆 ADMA 及其相关参数。如预期的那样，患有 PHT 的 HbSS/HbSβ(0)-地中海贫血患者的 ADMA 水平较高（p=0.018），但与无这些并发症的患者相比，患有其他与溶血相关的并发症（如腿部溃疡（p=0.012）、胆石症（p=0.008）和阴茎异常勃起（p=0.02）的患者的 ADMA 水平也较高。ADMA 水平在有或无其他疾病相关并发症（如视网膜病变和无血管性骨坏死）的患者之间没有差异。因此，较高的 ADMA 浓度似乎与 SCD 的溶血性表型有关。
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