Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Neurosurg Rev. 2010 Apr;33(2):185-91; discussion 191-2. doi: 10.1007/s10143-010-0243-z. Epub 2010 Feb 26.
The extent of resection is the most consistent factor affecting outcome of intracranial ependymomas. The outcomes in patients with intracranial anaplastic ependymomas who underwent more than subtotal resection and intensive treatment for recurrence were reviewed retrospectively. Between 1989 and 2007, 18 patients underwent more than subtotal resection at Tohoku University Hospital. Adjuvant chemoradiation therapy was conducted in 16 patients. Meticulous follow-up was performed for early detection of recurrence. Intensive therapy including surgery and chemoradiation therapy was added for recurrence. Median survival in all 18 patients was 136 months. The 5- and 10-year survival rates were 59.1% and 50.7%, respectively. Eight patients died during the observation period, five of dissemination, but none of uncontrollable local recurrence. High resection rate, meticulous follow-up, and intensive treatment for recurrence improved the survival of patients with anaplastic ependymoma. Dissemination was the life-determining factor in this series of patients.
切除范围是影响颅内室管膜瘤患者预后的最一致因素。回顾性分析了在东北大学医院接受超过次全切除和复发强化治疗的颅内间变性室管膜瘤患者的结果。1989 年至 2007 年间，18 名患者在东北大学医院接受了超过次全切除术。16 名患者接受了辅助放化疗。对复发进行了精心随访以早期发现。对于复发，采用手术和放化疗等强化治疗。18 名患者的中位生存期为 136 个月。5 年和 10 年生存率分别为 59.1%和 50.7%。观察期间有 8 名患者死亡，5 例为播散，但均无不可控局部复发。高切除率、精心随访和对复发的强化治疗改善了间变性室管膜瘤患者的生存。在本系列患者中，播散是决定生死的因素。
