Division of Health Behavior Research, Departments of Medicine and Pediatrics, School of Medicine, Washington University, Saint Louis, MO, USA.
Department of Epidemiology and Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
J Urban Health. 2010 Mar;87(2):199-210. doi: 10.1007/s11524-009-9426-8.
Adverse housing and neighborhood conditions are independently associated with an increased risk of various diseases and conditions. One possible explanation relates to systemic inflammation, which is associated with these adverse health outcomes. The authors investigated the association between housing and neighborhood conditions with inflammatory markers using data about 352 persons aged 49-65 years from the African American Health study. Participants were identified by a multistage random selection process in 2000 to 2001(response rate, 76%). Blood was analyzed for soluble cytokine receptors (interleukin-6, tumor necrosis factor alpha), C-reactive protein, and adiponectin. Neighborhood and housing characteristics consisted of five observed block face conditions (external appearance of the block on which the subject lived), four perceived neighborhood conditions, four observed housing conditions (home assessment by the interviewers rating the interior and exterior of the subject's building), and census-tract level poverty rate from the 2000 census. Differences in some inflammatory markers were found by age, gender, chronic conditions, and body mass index (all Bonferroni-adjusted p < 0.0034). There was no association between any of the housing/neighborhood conditions and the pro-inflammatory markers and potential associations between some housing/neighborhood conditions and adiponectin (p < 0.05, Bonferroni-adjusted p > 0.0034). Inflammation does not appear to be a mediator of the association between poor housing/neighborhood conditions and adverse health outcomes in middle-aged African Americans.
住房和邻里环境条件不良与各种疾病和状况的风险增加有关。一种可能的解释与系统性炎症有关，炎症与这些不良健康结果有关。作者利用来自非裔美国人健康研究的 352 名年龄在 49-65 岁之间的参与者的数据，调查了住房和邻里环境条件与炎症标志物之间的关系。这些参与者是通过 2000 年至 2001 年的多阶段随机选择过程确定的（应答率为 76%）。血液被分析用于可溶性细胞因子受体（白细胞介素-6、肿瘤坏死因子-α）、C 反应蛋白和脂联素。邻里和住房特征包括五个观察到的街区面貌条件（居住的街区的外观）、四个感知的邻里条件、四个观察到的住房条件（由访谈者对被试的建筑物内部和外部进行评估的住房评估）和 2000 年人口普查的普查区贫困率。一些炎症标志物的差异与年龄、性别、慢性疾病和体重指数有关（所有 Bonferroni 调整后的 p < 0.0034）。任何住房/邻里条件与促炎标志物之间均无关联，而一些住房/邻里条件与脂联素之间存在潜在关联（p < 0.05，Bonferroni 调整后 p > 0.0034）。炎症似乎不是导致中年非裔美国人不良住房/邻里条件与不良健康结果之间关联的中介因素。
