Department of Mechanical Engineering and Engineering Science, The University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA.
J Biomed Mater Res A. 2010 Jul;94(1):308-16. doi: 10.1002/jbm.a.32705.
Polymethylmethacrylate (PMMA) beads have been widely used in the treatment of bone infection over the last three decades. Although PMMA does offer a mechanism to quickly and effectively administer a localized dose of antibiotic to the site of infection, its efficacy is limited by its nonresorbability and nonbioactivity. Resorbable bioactive silica-calcium phosphate nanocomposite (SCPC75) was investigated as a novel controlled release carrier of vancomycin for the treatment of osteomyelitis. SCPC75 particles adsorbed significantly higher amount of vancomycin compared with PMMA. Moreover, SCPC75 provided a sustained release kinetics of therapeutic dose of vancomycin up to 35 days. The novel resorbable ceramic was able to release 95.5% of the adsorbed drug in an average dose of 12 microg/mL/day over 480 h (35 days). In conjunction with the sustained drug release, a controlled dissolution rate that led to 40% mass loss of SCPC75 was observed. On the other hand, PMMA provided a sustained release of a therapeutic dose of vancomycin for 14 days after which minimal concentration of the drug was detected. Moreover, PMMA retained 32% of the drug adsorbed onto its surface. The SCPC-vancomycin implant can serve a dual function: provide a sustained therapeutic dose of antibiotic to eradicate infection and stimulate bone cell differentiation and new bone formation. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010.
聚甲基丙烯酸甲酯（PMMA）珠在过去三十年中已被广泛用于治疗骨感染。尽管 PMMA 确实提供了一种机制，可以快速有效地将局部剂量的抗生素施用于感染部位，但它的疗效受到其不可吸收性和非生物活性的限制。可吸收的生物活性硅钙磷酸纳米复合材料（SCPC75）被研究作为万古霉素的新型控释载体，用于治疗骨髓炎。与 PMMA 相比，SCPC75 颗粒吸附了明显更多量的万古霉素。此外，SCPC75 提供了高达 35 天的治疗剂量万古霉素的持续释放动力学。这种新型可吸收陶瓷能够在 480 小时（35 天）内以平均剂量 12 微克/毫升/天的速度释放 95.5%的吸附药物。与持续的药物释放相结合，观察到 SCPC75 的溶解率得到控制，导致其质量损失 40%。另一方面，PMMA 在 14 天后提供了治疗剂量万古霉素的持续释放，此后检测到药物的最小浓度。此外，PMMA 保留了其表面吸附的 32%的药物。SCPC-万古霉素植入物可以发挥双重作用：提供持续的治疗剂量抗生素以消除感染，并刺激骨细胞分化和新骨形成。（c）2010 Wiley 期刊，Inc. J Biomed Mater Res，2010。
