Department of Polymeric Biomaterials and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan, People's Republic of China.
J Biomed Mater Res B Appl Biomater. 2010 May;93(2):497-509. doi: 10.1002/jbm.b.31609.
Fluoropassivation and gelatin coating have been applied to polyethylene terephthalate (PET) vascular prosthesis to combine the advantages of both polytetrafluoroethylene (PTFE) and PET materials, and to eliminate the preclotting procedure. The morphological, chemical, physical, and mechanical properties of such prostheses were investigated and compared with its original model. Fluoropassivation introduced -OCF(3), -CF(3), and -CFCF(2)- structures onto the surface of the polyester fibers. However, the surface fluorine content was only 28-32% compared to the 66% in expanded PTFE (ePTFE) grafts. The fluoropassivation decreased the hydrophilicity, slightly increased the water permeability, and marginally lowered the melting point and the crystallinity of the PET fibers. After gelatin coating, the fluoropassivated and nonfluoropassivated prostheses showed similar surface morphology and chemistry. While gelatin coating eliminated preclotting, it also renders the prostheses slightly stiffer. The original prosthesis had the highest bursting strength (275 N), with the fluoropassivated and gelatin-sealed devices showing similar bursting strength between 210 and 230 N. Fluoropassivation and gelatin coating lowered the retention strength by 23 and 30% on average, respectively. In vitro enzymatic incubation had only marginal effect on the surface fluorine content of the nongelatin-sealed prostheses. However, the gelatin-sealed ones significantly lost their surface fluorine after in vitro enzymatic incubation (by 69-85%) or in vivo 6-month implantation (by 51-60%), showing the lability of the fluoropolymer layer under the hostile biological environment.
聚对苯二甲酸乙二醇酯（PET）血管移植物经过氟钝化和明胶涂层处理，结合了聚四氟乙烯（PTFE）和 PET 材料的优点，同时消除了预凝块过程。研究并比较了这种移植物的形态、化学、物理和机械性能与其原始模型。氟钝化在聚酯纤维表面引入了 -OCF(3)、-CF(3) 和 -CFCF(2)-结构。然而，与膨体 PTFE（ePTFE）移植物中的 66%相比，表面氟含量仅为 28-32%。氟钝化降低了亲水性，略微提高了水渗透性，略微降低了 PET 纤维的熔点和结晶度。经过明胶涂层处理后，氟钝化和非氟钝化的移植物表现出相似的表面形貌和化学性质。虽然明胶涂层消除了预凝块，但也使移植物略微变硬。原始移植物的爆裂强度最高（275N），氟钝化和明胶密封装置的爆裂强度相似，在 210-230N 之间。氟钝化和明胶涂层分别使保留强度平均降低了 23%和 30%。体外酶孵育对未密封明胶的移植物表面氟含量仅有轻微影响。然而，密封明胶的移植物在体外酶孵育（69-85%）或体内 6 个月植入（51-60%）后，其表面氟明显损失，表明氟聚合物层在恶劣的生物环境下不稳定。
