Grimbert F, Reynaert M, Perret C
Bull Eur Physiopathol Respir. 1977 Sep-Oct;13(5):659-67.
The acid-base values of 13 patients with stable carbon dioxide tensions under controlled ventilation have been used to define the response to chronic hypocapnia in man. These patients had a respiratory paralysis and no apparent complicating disorders. Over a range of carbon dioxide tensions from 24 to 40 millimetres of mercury, the arterial blood hydrogen ion concentration decreased linearly by 0.32 nanomole per litre per millimetre of mercury decrement in carbon dioxide tension. Of primary interest was the finding that the slope of the regression line in chronic hypocapnia is close to that already reported for chronic hypercapnia. The physiological response to chronic hypocapnia in man is defined by a band that is approximately 10 nanomoles per litre (0.09 pH unit) wide for hydrogen ion concentration and 6 millimoles per litre wide for bicarbonate concentration. These significance bands may be used to differentiate additional acid-base disorders in patients with chronic hypocapnia over a clinically useful range of carbon dioxide tensions.
在控制通气条件下，对13名二氧化碳分压稳定的患者的酸碱值进行了研究，以确定人类对慢性低碳酸血症的反应。这些患者患有呼吸麻痹且无明显并发疾病。在24至40毫米汞柱的二氧化碳分压范围内，随着二氧化碳分压每降低1毫米汞柱，动脉血氢离子浓度线性下降0.32纳摩尔/升。主要的发现是，慢性低碳酸血症时回归线的斜率与已报道的慢性高碳酸血症时的斜率相近。人类对慢性低碳酸血症的生理反应由一个范围界定，即氢离子浓度约为10纳摩尔/升（0.09个pH单位），碳酸氢盐浓度约为6毫摩尔/升。这些有意义的范围可用于在临床上有用的二氧化碳分压范围内区分慢性低碳酸血症患者的其他酸碱紊乱。
