Department of Radiology, University of California, San Francisco, California 94143-0628, USA.
J Magn Reson Imaging. 2010 Mar;31(3):711-8. doi: 10.1002/jmri.22083.
To show that 4D Flow is a clinically viable tool for evaluation of collateral blood flow and demonstration of distorted blood flow patterns in patients with treated and untreated aortic coarctation.
Time-resolved, 3D phase contrast magnetic resonance imaging (MRI) (4D Flow) was used to assess blood flow in the thoracic aorta of 34 individuals: 26 patients with coarctation (22 after surgery or stent placement) and eight healthy volunteers.
Direct comparison of blood flow calculated with 2D and 4D phase contrast data at standard levels for analysis in coarctation patients showed good correlation and agreement (correlation coefficient r = 0.99, limits of agreement = -20% to 20% for collateral blood flow calculations). Abnormal blood flow patterns were demonstrated at peak systole with 4D Flow visualization techniques in the descending thoracic aorta of patients but not volunteers. Marked helical flow was seen in 9 of 13 patients with angulated aortic arch geometries after coarctation repair. Vortical flow was seen in regions of poststenotic dilation.
4D Flow is a fast and reliable means of evaluating collateral blood flow in patients with aortic coarctation in order to establish hemodynamic significance. It also can detect distorted blood flow patterns in the descending aorta after coarctation repair.
展示 4D Flow 是一种临床可行的工具，可用于评估治疗和未治疗的主动脉缩窄患者的侧支血流，并显示扭曲的血流模式。
使用时间分辨、3D 相位对比磁共振成像（MRI）（4D Flow）评估 34 个人的胸主动脉血流：26 例缩窄患者（22 例经手术或支架置入治疗）和 8 名健康志愿者。
在标准水平上直接比较分析缩窄患者时使用 2D 和 4D 相位对比数据计算的血流，显示出良好的相关性和一致性（相关系数 r = 0.99，协方差界限为 20%至 20%，用于侧支血流计算）。在缩窄修复后的降主动脉中，4D Flow 可视化技术显示出患者而非志愿者在峰值收缩期的异常血流模式。在 13 例主动脉弓几何形状呈角度的患者中，有 9 例可见明显的螺旋血流。在狭窄后扩张区域可见涡流血流。
4D Flow 是一种快速可靠的评估主动脉缩窄患者侧支血流的方法，用于确定血流动力学意义。它还可以检测缩窄修复后降主动脉的扭曲血流模式。
