Halayem Soumeyya, Bouden Asma, Amado Isabelle, Krebs Marie-Odile, Tabbane Karim, Halayem Mohamed
Unité de recherche Processus cognitifs dans la pathologie psychiatrique, Service de Psychiatrie B, Hôpital Razi, La Manouba.
Tunis Med. 2009 Oct;87(10):651-5.
Neurological soft signs (NSS) are endophenotypic markers of schizophrenia, and their high prevalence in pervasive developmental disorders (PDD) support the existence of the spectrum of psychoses. These NSS were evaluated by standardized scales which were not adapted to children with PDD.
This study aimed to propose an adaptation for children of a scale of NSS already used in adults.
21 children with PDD (11 with autistic disorder, 10 with PDD not otherwise specified) aged 6-12 years and 21 controls matched on age, sex, and cognitive level were included. Evaluating tools were NSS scale of Krebs et al. adapted after a pilot-study with the accordance of its author; the Progressive Matrices of Raven for intellectual level, and ADI-R to confirm diagnosis.
Patients were significantly more impaired on total score (p=0,001), motor coordination (p=0,008), motor integration (p=0,000), and sensory integration (p=0,001). There were no difference between patients and controls on abnormal movements and quality of lateralization.
This adaptation of Krebs et al. scale seems to be a good tool for evaluating NSS in children, especially in those with PDD. A further validation study, including a larger sample is necessary.
神经软体征（NSS）是精神分裂症的内表型标志物，其在广泛性发育障碍（PDD）中的高患病率支持了精神病谱系的存在。这些NSS通过未适用于PDD儿童的标准化量表进行评估。
本研究旨在对已在成人中使用的NSS量表进行儿童版改编。
纳入21名6至12岁的PDD儿童（11名自闭症谱系障碍儿童，10名未特定的PDD儿童）以及21名年龄、性别和认知水平相匹配的对照。评估工具包括经作者同意在预试验后改编的Krebs等人的NSS量表；用于评估智力水平的瑞文渐进矩阵测验，以及用于确诊的孤独症诊断访谈修订版（ADI-R）。
患者在总分（p = 0.001）、运动协调（p = 0.008）、运动整合（p = 0.000）和感觉整合（p = 0.001）方面的受损程度明显更高。患者和对照在异常运动和偏侧化质量方面无差异。
Krebs等人量表的这种改编似乎是评估儿童尤其是PDD儿童NSS的良好工具。有必要进行进一步的验证研究，包括更大的样本量。
