Jemeleddine Eyatollah, Bouden Asma, Halayem Soumeyya, Othman Sami, Tabbane Karim, Halayem Mohamed
Unité recherche Processus cognitifs dans la pathologie psychiatrique, Service de Psychiatrie B, Hôpital Razi, La Manouba.
Tunis Med. 2009 Oct;87(10):656-9.
This study aimed to evaluate basic performances on verbal memory in treatment-naïve children and adolescents with depression and in healthy control subjects.
34 children and adolescents aged 6-16 years, suffering from a first major depressive disorder (DSM IV) and 34 controls matched on sex, age and cognitive ability were evaluated. Psychiatric diagnosis was assessed with the K-SADS-PL. The Child Depression Rating Scale (CDRS) was used to assess the severity of depression. Progressive matrices of Raven were used to evaluate intelligence. Two different cognitive tasks were administered to assess semantic and working memory: digit span test, and semantic and phonemic verbal fluency.
A significant effect of diagnosis was found for digit span: patients showed lower performance on forward (p=0,015) and backward (p=0,002) digits. No difference was found between patients and controls on verbal fluency. The young age of the sample and the first depressive episode criteria may explain the absence of severe impairment of this type of semantic and working memory.
These results support the hypothesis that memory deficits in depressive disorders are partly the result of poor encoding caused by a deficit in attention.
本研究旨在评估初治的抑郁症儿童和青少年以及健康对照受试者在言语记忆方面的基本表现。
对34名年龄在6至16岁、患有首次重度抑郁症（DSM-IV）的儿童和青少年以及34名在性别、年龄和认知能力上匹配的对照者进行评估。使用K-SADS-PL评估精神科诊断。儿童抑郁评定量表（CDRS）用于评估抑郁的严重程度。使用瑞文渐进矩阵来评估智力。进行两项不同的认知任务以评估语义和工作记忆：数字广度测试以及语义和音素言语流畅性测试。
在数字广度方面发现了显著的诊断效应：患者在顺背（p = 0.015）和倒背（p = 0.002）数字上表现较差。在言语流畅性方面，患者与对照者之间未发现差异。样本的年轻年龄和首次抑郁发作标准可能解释了这种语义和工作记忆未出现严重损害的情况。
这些结果支持了以下假设，即抑郁症中的记忆缺陷部分是由注意力缺陷导致的编码不良所致。
