Johnson Ines, Ben Azouz Olfa, Kebir Oussama, Dellagi Lamia, Amado Isabelle, Tabbane Karim
Unité de recherche UR 02/04 sur les processus cognitifs dans la pathologie psychiatrique, hôpital Razi, Tunis.
Tunis Med. 2009 Oct;87(10):664-9.
Schizophrenia is characterised by positive and negative symptoms as well as thought disorders and disorganised behaviour. Multiple cognitive deficits within the areas of memory, attention and executive functions are also associated with schizophrenia. Aim of the study was to proceed to a study of correlations between clinical dimensions of schizophrenia and cognitive functions.
The authors recruited 105 patients suffering from schizophrenia spectrum disorders (DSM IV criteria). The patients were clinically stabilised, showing no depressive state at the time of the study, with no organic brain disorders and no history of drug intake. They were clinically evaluated using the PANSS and the Calgary Depression Scale. A cognitive battery was also administered.
Positive dimension of schizophrenia was shown to be independent from any cognitive function. Disorganisation was negatively correlated to attention, working memory, long-term verbal memory and executive functions. Negative dimension was negatively correlated with working memory and executive functions.
Cognition wasn't correlated to the positive dimension of schizophrenia whereas it was correlated to the negative and to the disorganisation dimension of the disease. This is probably due to overlapping of concepts.
精神分裂症的特征包括阳性和阴性症状、思维障碍以及行为紊乱。记忆、注意力和执行功能等多个认知领域的缺陷也与精神分裂症有关。本研究的目的是对精神分裂症的临床维度与认知功能之间的相关性进行研究。
作者招募了105名患有精神分裂症谱系障碍（符合DSM-IV标准）的患者。这些患者临床症状稳定，在研究时未表现出抑郁状态，没有器质性脑疾病且无药物摄入史。使用阳性和阴性症状量表（PANSS）及卡尔加里抑郁量表对他们进行临床评估。同时还进行了一组认知测试。
精神分裂症的阳性维度与任何认知功能均无关。紊乱维度与注意力、工作记忆、长期言语记忆及执行功能呈负相关。阴性维度与工作记忆和执行功能呈负相关。
认知与精神分裂症的阳性维度无关，而与该疾病的阴性维度和紊乱维度相关。这可能是由于概念重叠所致。
